U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Edg84A Ecdysone-dependent gene 84A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40818, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Edg84Aprovided by FlyBase
Official Full Name
Ecdysone-dependent gene 84Aprovided by FlyBase
Primary source
FLYBASE:FBgn0000552
Locus tag
Dmel_CG2345
See related
AllianceGenome:FB:FBgn0000552
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG:DS00004.8; cc1; CG2345; DM-EDG84; DmelEDG84A; Dmel\CG2345; EDG-84; EDG-84A; Edg84; EDG84; EDG84A
Summary
Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in epidermis; larval head; and larval thorax. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Edg84A in Genome Data Viewer
Location:
84A1-84A1; 3-48 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6684445..6685157)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2510173..2510855)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene twisted bristles roughened eye Neighboring gene O-6-alkylguanine-DNA alkyltransferase Neighboring gene labial Neighboring gene Ccp84Ag Neighboring gene Ccp84Af

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification and characterisation of the Drosophila melanogaster O6-alkylguanine-DNA alkyltransferase cDNA. Kooistra R, et al. Nucleic Acids Res, 1999 Apr 15. PMID 10101186, Free PMC Article
  2. 20-Hydroxyecdysone is required for, and negatively regulates, transcription of Drosophila pupal cuticle protein genes. Apple RT, et al. Dev Biol, 1991 Aug. PMID 1713868
  3. Regulation of the EDG84A gene by FTZ-F1 during metamorphosis in Drosophila melanogaster. Murata T, et al. Mol Cell Biol, 1996 Nov. PMID 8887679, Free PMC Article
  4. Isolation and characterization of drosocrystallin, a lens crystallin gene of Drosophila melanogaster. Janssens H, et al. Dev Biol, 1999 Mar 1. PMID 10049575
  5. Anterior epidermis-specific expression of the cuticle gene EDG84A is controlled by many cis-regulatory elements in Drosophila melanogaster. Kayashima Y, et al. Dev Genes Evol, 2005 Nov. PMID 16025347

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DHR3 and betaFTZ-F1 activate the EDG84A gene in a redundant manner. The temporal expression of the EDG84A gene is mainly controlled by betaFTZ-F1 but that the binding of DHR3 is also important.
    Title: The binding of multiple nuclear receptors to a single regulatory region is important for the proper expression of EDG84A in Drosophila melanogaster.
  2. The EDG84A gene encoding pupal cuticle protein is one of the targets of ecdysteroid-inducible transcription factor betaFTZ-F1 and is expressed only in anterior epidermis of the body during mid- to late prepupal period.
    Title: Anterior epidermis-specific expression of the cuticle gene EDG84A is controlled by many cis-regulatory elements in Drosophila melanogaster.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables structural constituent of chitin-based larval cuticle ISM
Inferred from Sequence Model
more info
 PubMed 
enables structural constituent of pupal chitin-based cuticle TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in chitin-based cuticle development ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
located_in chitin-based extracellular matrix ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Ecdysone-dependent gene 84A
Names
CG2345-PA
Edg84A-PA
cuticle cluster 1
cuticle-like cluster
ecdysone-dependent gene-84A-1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    6684445..6685157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079523.3 → NP_524247.1  Ecdysone-dependent gene 84A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524247.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P27780, Q9VI43
    UniProtKB/TrEMBL
    D0IQB7
    Related
    FBpp0081186
    Conserved Domains (1) summary
    pfam00379
    Location:37 → 89
    Chitin_bind_4; Insect cuticle protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27780.1 P27780

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools