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MIR17HG miR-17-92a-1 cluster host gene [ Homo sapiens (human) ]

Gene ID: 407975, updated on 27-Nov-2024

Summary

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Official Symbol
MIR17HGprovided by HGNC
Official Full Name
miR-17-92a-1 cluster host geneprovided by HGNC
Primary source
HGNC:HGNC:23564
See related
Ensembl:ENSG00000215417 MIM:609415; AllianceGenome:HGNC:23564
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIHG1; MIRH1; MIRHG1; C13orf25; LINC00048; miR-17-92; NCRNA00048
Summary
This gene is the host gene for the MIR17-92 cluster, a group of at least six microRNAs (miRNAs) that may be involved in cell survival, proliferation, differentiation, and angiogenesis. Amplification of this gene has been found in several lymphomas and solid tumors. Two non-protein coding transcript variants have been found for this host gene, but only the longest is a polycistronic transcript containing the MIR17-92 cluster. [provided by RefSeq, May 2012]
Expression
Ubiquitous expression in lymph node (RPKM 1.4), appendix (RPKM 1.3) and 25 other tissues See more
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Genomic context

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See MIR17HG in Genome Data Viewer
Location:
13q31.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (91347687..91354577)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (90550261..90557153)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (91999941..92006831)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370313 Neighboring gene uncharacterized LOC105370314 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:91977821-91978041 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:91988812-91988986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5431 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:92001527-92002074 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:92000979-92001526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7863 Neighboring gene peptidylprolyl isomerase A pseudogene 23 Neighboring gene uncharacterized LOC124903189 Neighboring gene Sharpr-MPRA regulatory region 6090 Neighboring gene microRNA 19b-1 Neighboring gene microRNA 92a-1 Neighboring gene microRNA 18a Neighboring gene microRNA 19a Neighboring gene microRNA 20a Neighboring gene microRNA 17 Neighboring gene glypican 5 Neighboring gene RNA, U4atac small nuclear 3, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MicroRNA-17-92 cluster promotes the proliferation and the chemokine production of keratinocytes: implication for the pathogenesis of psoriasis. Zhang W, et al. Cell Death Dis, 2018 May 1. PMID 29752469, Free PMC Article
  2. MiR-17-92 represses PTPROt and PP2A phosphatases and amplifies tonic BCR signaling in DLBCL cells. Jablonska E, et al. Exp Hematol, 2017 Feb. PMID 27720936
  3. The role of the miR-17-92 cluster in neurogenesis and angiogenesis in the central nervous system of adults. Yang P, et al. J Neurosci Res, 2017 Aug. PMID 27869313
  4. The role of miR-17-92 in the miRegulatory landscape of Ewing sarcoma. Schwentner R, et al. Oncotarget, 2017 Feb 14. PMID 28030800, Free PMC Article
  5. MicroRNA-mediated positive feedback loop and optimized bistable switch in a cancer network Involving miR-17-92. Li Y, et al. PLoS One, 2011. PMID 22022595, Free PMC Article

See all (132) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA MIR17HG promotes colorectal cancer liver metastasis by mediating a glycolysis-associated positive feedback circuit.
    Title: LncRNA MIR17HG promotes colorectal cancer liver metastasis by mediating a glycolysis-associated positive feedback circuit.
  2. Association between Mir-17-92 gene promoter polymorphisms and depression in a Chinese population.
    Title: Association between Mir-17-92 gene promoter polymorphisms and depression in a Chinese population.
  3. Downregulation of lncRNA MIR17HG reduced tumorigenicity and Treg-mediated immune escape of non-small-cell lung cancer cells through targeting the miR-17-5p/RUNX3 axis.
    Title: Downregulation of lncRNA MIR17HG reduced tumorigenicity and Treg-mediated immune escape of non-small-cell lung cancer cells through targeting the miR-17-5p/RUNX3 axis.
  4. Bioinformatics analysis proposes a possible role for long noncoding RNA MIR17HG in retinoblastoma.
    Title: Bioinformatics analysis proposes a possible role for long noncoding RNA MIR17HG in retinoblastoma.
  5. LncRNA MIR17HG Suppresses Breast Cancer Proliferation and Migration as ceRNA to Target FAM135A by Sponging miR-454-3p.
    Title: LncRNA MIR17HG Suppresses Breast Cancer Proliferation and Migration as ceRNA to Target FAM135A by Sponging miR-454-3p.
  6. Exosomal miR-17-92 derived from human mesenchymal stem cells promotes wound healing by enhancing angiogenesis and inhibiting endothelial cell ferroptosis.
    Title: Exosomal miR-17-92 derived from human mesenchymal stem cells promotes wound healing by enhancing angiogenesis and inhibiting endothelial cell ferroptosis.
  7. Prognostic Value of the miR-17~92 Cluster in Chronic Lymphocytic Leukemia.
    Title: Prognostic Value of the miR-17~92 Cluster in Chronic Lymphocytic Leukemia.
  8. The miR-17-92 cluster: Yin and Yang in human cancers.
    Title: The miR-17-92 cluster: Yin and Yang in human cancers.
  9. Genetic variant in miR-17-92 cluster binding sites is associated with esophageal squamous cell carcinoma risk in Chinese population.
    Title: Genetic variant in miR-17-92 cluster binding sites is associated with esophageal squamous cell carcinoma risk in Chinese population.
  10. Overexpression of the miR-17-92 cluster in colorectal adenoma organoids causes a carcinoma-like gene expression signature.
    Title: Overexpression of the miR-17-92 cluster in colorectal adenoma organoids causes a carcinoma-like gene expression signature.
Submit: New GeneRIF Correction See all GeneRIFs (116)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • MIR17 host gene (non-protein coding)
  • long intergenic non-protein coding RNA 48
  • miR-17-92 cluster host gene (non-protein coding)
  • microRNA host gene (non-protein coding) 1
  • microRNA host gene 1 (non-protein coding)
  • mir-17-92 microRNA cluster

Clone Names

  • FLJ14178, MGC126270

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in B cell homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cardiac right ventricle morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lung growth ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in miRNA-mediated post-transcriptional gene silencing IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of negative regulation of B cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cardiac muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in outflow tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cardiac muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of muscle hyperplasia IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of B cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of regulation of B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ventricular septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032702.1 RefSeqGene

    Range
    5001..11756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_027349.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two internal segments compared to variant 1. This transcript lacks the MIR17-92 cluster of miRNAs found in variant 1.
    Source sequence(s)
    AL138714, AL162375
    Related
    ENST00000710420.1

  2. NR_027350.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and contains the MIR17-92 cluster of miRNAs.
    Source sequence(s)
    AL138714, AL162375
    Related
    ENST00000582141.6

  3. NR_197388.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL138714, AL162375

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    91347687..91354577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    90550261..90557153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_213723.1: Suppressed sequence

    Description
    NM_213723.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.

  2. NM_213724.1: Suppressed sequence

    Description
    NM_213724.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
Nucleotide Protein
Heading Accession and Version

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