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CG2017 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40733, updated on 9-Dec-2024

Summary

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Official Symbol
CG2017provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037391
Locus tag
Dmel_CG2017
See related
AllianceGenome:FB:FBgn0037391
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG 2017; Dmel\CG2017
Summary
Predicted to enable GTP binding activity; alpha-aminoacyl-tRNA binding activity; and translation elongation factor activity. Predicted to be involved in translational elongation. Used to study syndromic intellectual disability. Orthologous to human GTPBP2 (GTP binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG2017 in Genome Data Viewer
Location:
83C5-83C6; 3-47.5 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5858083..5862405, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1683805..1688127, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46133 Neighboring gene uncharacterized protein Neighboring gene dispatched Neighboring gene ECSIT Neighboring gene sidestep III Neighboring gene long non-coding RNA:CR45761 Neighboring gene long non-coding RNA:CR45762

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bi-allelic genetic variants in the translational GTPases GTPBP1 and GTPBP2 cause a distinct identical neurodevelopmental syndrome. Salpietro V, et al. Am J Hum Genet, 2024 Jan 4. PMID 38118446, Free PMC Article
  2. Chromatin-mediated microtubule nucleation in Drosophila syncytial embryos. Hayward D, et al. Commun Integr Biol, 2014. PMID 25053984, Free PMC Article
  3. miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila. Pandey M, et al. Elife, 2021 Jun 8. PMID 34100717, Free PMC Article
  4. A screen for modifiers of RacGAP(84C) gain-of-function in the Drosophila eye revealed the LIM kinase Cdi/TESK1 as a downstream effector of Rac1 during spermatogenesis. Raymond K, et al. J Cell Sci, 2004 Jun 1. PMID 15169836
  5. New comparative genomics approach reveals a conserved health span signature across species. Antosh M, et al. Aging (Albany NY), 2011 Jun. PMID 21775776, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bi-allelic genetic variants in the translational GTPases GTPBP1 and GTPBP2 cause a distinct identical neurodevelopmental syndrome.
    Title: Bi-allelic genetic variants in the translational GTPases GTPBP1 and GTPBP2 cause a distinct identical neurodevelopmental syndrome.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-aminoacyl-tRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG2017-PA
CG2017-PB
CG2017-PC
CG2017-PD
CG2017-PE
GP-1 related

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5858083..5862405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169117.2 → NP_731026.1  uncharacterized protein Dmel_CG2017, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731026.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86BS2
    Related
    FBpp0078311
    Conserved Domains (4) summary
    cd04165
    Location:178 → 397
    GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
    COG5258
    Location:61 → 596
    GTPBP1; GTPase [General function prediction only]
    cd03694
    Location:411 → 497
    GTPBP_II; Domain II of the GTPBP family of GTP binding proteins
    cd03708
    Location:508 → 595
    GTPBP_III; Domain III of the GP-1 family of GTPases

  2. NM_141346.3 → NP_649603.3  uncharacterized protein Dmel_CG2017, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649603.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960F7, Q9VNJ7
    Related
    FBpp0078310
    Conserved Domains (4) summary
    cd04165
    Location:217 → 436
    GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
    COG5258
    Location:100 → 635
    GTPBP1; GTPase [General function prediction only]
    cd03694
    Location:450 → 536
    GTPBP_II; Domain II of the GTPBP family of GTP binding proteins
    cd03708
    Location:547 → 634
    GTPBP_III; Domain III of the GP-1 family of GTPases

  3. NM_169116.2 → NP_731025.1  uncharacterized protein Dmel_CG2017, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731025.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86BS2
    Related
    FBpp0078312
    Conserved Domains (4) summary
    cd04165
    Location:178 → 397
    GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
    COG5258
    Location:61 → 596
    GTPBP1; GTPase [General function prediction only]
    cd03694
    Location:411 → 497
    GTPBP_II; Domain II of the GTPBP family of GTP binding proteins
    cd03708
    Location:508 → 595
    GTPBP_III; Domain III of the GP-1 family of GTPases

  4. NM_169115.2 → NP_731024.1  uncharacterized protein Dmel_CG2017, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731024.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86BS2
    Related
    FBpp0078313
    Conserved Domains (4) summary
    cd04165
    Location:178 → 397
    GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
    COG5258
    Location:61 → 596
    GTPBP1; GTPase [General function prediction only]
    cd03694
    Location:411 → 497
    GTPBP_II; Domain II of the GTPBP family of GTP binding proteins
    cd03708
    Location:508 → 595
    GTPBP_III; Domain III of the GP-1 family of GTPases

  5. NM_001144540.2 → NP_001138012.1  uncharacterized protein Dmel_CG2017, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138012.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86BS2
    Conserved Domains (4) summary
    cd04165
    Location:178 → 397
    GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
    COG5258
    Location:61 → 596
    GTPBP1; GTPase [General function prediction only]
    cd03694
    Location:411 → 497
    GTPBP_II; Domain II of the GTPBP family of GTP binding proteins
    cd03708
    Location:508 → 595
    GTPBP_III; Domain III of the GP-1 family of GTPases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86BS2 Q86BS2
Q960F7 Q960F7

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