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ECSIT ECSIT [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40732, updated on 4-Jan-2025

Summary

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Official Symbol
ECSITprovided by FlyBase
Official Full Name
ECSITprovided by FlyBase
Primary source
FLYBASE:FBgn0028436
Locus tag
Dmel_CG10610
See related
AllianceGenome:FB:FBgn0028436
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10610; dECSIT; DmECSIT; Dmel\CG10610
Summary
Involved in innate immune response. Is active in mitochondrion. Is expressed in several structures, including adult head; adult heart; larval muscle system; and visceral muscle cell. Orthologous to human ECSIT (ECSIT signaling integrator). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See ECSIT in Genome Data Viewer
Location:
83C5-83C5; 3-47.5 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5856585..5857914)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1682307..1683636)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene antisense RNA:CR46133 Neighboring gene uncharacterized protein Neighboring gene dispatched Neighboring gene uncharacterized protein Neighboring gene sidestep III Neighboring gene long non-coding RNA:CR45761

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology. Wu H, et al. Bioessays, 2003 Nov. PMID 14579250
  2. Toll-like receptors in the induction of the innate immune response. Aderem A, et al. Nature, 2000 Aug 17. PMID 10963608
  3. A heterotrimeric death domain complex in Toll signaling. Sun H, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12351681, Free PMC Article
  4. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Kopp E, et al. Genes Dev, 1999 Aug 15. PMID 10465784, Free PMC Article
  5. Dissecting the concordant and disparate roles of NDUFAF3 and NDUFAF4 in mitochondrial complex I biogenesis. Murari A, et al. iScience, 2021 Aug 20. PMID 34386730, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein serine/threonine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of oxidoreductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein complex stability ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ECSIT
Names
CG10610-PA
ECSIT-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5856585..5857914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141345.2 → NP_649602.2  ECSIT [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649602.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SZF7, Q9U6M0, Q9VNJ6
    UniProtKB/TrEMBL
    B6IDJ7
    Related
    FBpp0078296, FBtr0078647
    Conserved Domains (3) summary
    sd00004
    Location:68 → 100
    PPR; PPR repeat [structural motif]
    pfam06239
    Location:42 → 242
    ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
    pfam14784
    Location:245 → 374
    ECIST_C; C-terminal domain of the ECSIT protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U6M0.2 Q9U6M0

Gene LinkOut

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