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ALOX12 arachidonate 12-lipoxygenase, 12S type [ Bos taurus (domestic cattle) ]

Gene ID: 407169, updated on 1-Jan-2025

Summary

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Official Symbol
ALOX12provided by VGNC
Official Full Name
arachidonate 12-lipoxygenase, 12S typeprovided by VGNC
Primary source
VGNC:VGNC:25841
See related
BGD:BT10598; Ensembl:ENSBTAG00000021933
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
12-LOX
Orthologs
human mouse all
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Genomic context

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See ALOX12 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (26787205..26800876)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112442630 Neighboring gene arachidonate lipoxygenase, epidermal Neighboring gene transcription initiation factor TFIID subunit 13-like Neighboring gene CUE domain-containing protein 2-like Neighboring gene uncharacterized LOC107131510 Neighboring gene chromosome 19 C17orf49 homolog Neighboring gene ribonuclease K

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. The scurs locus in cattle maps to bovine chromosome 19. Asai M, et al. Anim Genet, 2004 Feb. PMID 14731227
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables arachidonate 12(S)-lipoxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables arachidonate 15-lipoxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables linoleate 13S-lipoxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in arachidonate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hepoxilin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in linoleic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipid oxidation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipoxygenase pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
polyunsaturated fatty acid lipoxygenase ALOX12
NP_001179265.1
XP_005220252.1
XP_010814200.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001192336.1 → NP_001179265.1  polyunsaturated fatty acid lipoxygenase ALOX12

    See identical proteins and their annotated locations for NP_001179265.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000019
    UniProtKB/TrEMBL
    A0AAA9SHL6, F1MFA8
    Related
    ENSBTAP00000029240.5, ENSBTAT00000029240.7
    Conserved Domains (2) summary
    cd01753
    Location:2 → 111
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    cl27717
    Location:221 → 654
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    26787205..26800876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010815898.4 → XP_010814200.1  polyunsaturated fatty acid lipoxygenase ALOX12 isoform X1

    UniProtKB/TrEMBL
    A0AAA9SHL6, A0AAA9T1R8
    Related
    ENSBTAP00000090492.1, ENSBTAT00000125725.1
    Conserved Domains (2) summary
    cd01753
    Location:2 → 111
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    cl27717
    Location:221 → 597
    Lipoxygenase; Lipoxygenase

  2. XM_005220195.5 → XP_005220252.1  polyunsaturated fatty acid lipoxygenase ALOX12 isoform X2

    UniProtKB/TrEMBL
    A0AAA9SHL6
    Related
    ENSBTAP00000085696.1, ENSBTAT00000128624.1
    Conserved Domains (2) summary
    cd01753
    Location:2 → 111
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:221 → 547
    Lipoxygenase; Lipoxygenase
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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