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chst12a carbohydrate (chondroitin 4) sulfotransferase 12a [ Danio rerio (zebrafish) ]

Gene ID: 407076, updated on 4-Jan-2025

Summary

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Official Symbol
chst12aprovided by ZNC
Official Full Name
carbohydrate (chondroitin 4) sulfotransferase 12aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-081022-13
See related
Ensembl:ENSDARG00000028786 AllianceGenome:ZFIN:ZDB-GENE-081022-13
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
chst12; csht12; zC4ST-2; zgc:193508; zgc:193523
Summary
Predicted to enable sulfotransferase activity. Predicted to be involved in proteoglycan biosynthetic process. Predicted to act upstream of or within carbohydrate biosynthetic process. Predicted to be located in Golgi membrane. Is expressed in female organism; head; notochord; pectoral fin; and pharyngeal arch cartilage. Orthologous to human CHST12 (carbohydrate sulfotransferase 12). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See chst12a in Genome Data Viewer
Location:
chromosome: 3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (41731566..41732941)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (41589708..41591083)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein) alpha 12a Neighboring gene eukaryotic translation initiation factor 3, subunit Ba Neighboring gene QRFP-like peptide receptor Neighboring gene galectin-related inter-fiber protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chondroitin 4-O-sulfotransferase-1 is required for somitic muscle development and motor axon guidance in zebrafish. Mizumoto S, et al. Biochem J, 2009 Apr 15. PMID 19125692
  2. Chondroitin / dermatan sulfate modification enzymes in zebrafish development. Habicher J, et al. PLoS One, 2015. PMID 25793894, Free PMC Article
  3. Characterization of paralogous uncx transcription factor encoding genes in zebrafish. Nittoli V, et al. Gene X, 2019 Jun. PMID 31193955, Free PMC Article
  4. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article
  5. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carbohydrate sulfotransferase 12
Names
C4ST-2
carbohydrate (chondroitin 4) sulfotransferase 12
chondroitin 4-sulfotransferase-2
NP_998712.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213547.2 → NP_998712.2  carbohydrate sulfotransferase 12

    Status: VALIDATED

    Source sequence(s)
    BC162067
    UniProtKB/TrEMBL
    A0A2R8QL27, A0A8M1PJP0, A0A8N7XJ72, B3DFJ6, B3DFK7, F6PBU2
    Related
    ENSDARP00000153749.1, ENSDART00000187866.1
    Conserved Domains (1) summary
    pfam03567
    Location:182 → 427
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    41731566..41732941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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