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Atu Another transcription unit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40684, updated on 9-Dec-2024

Summary

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Official Symbol
Atuprovided by FlyBase
Official Full Name
Another transcription unitprovided by FlyBase
Primary source
FLYBASE:FBgn0019637
Locus tag
Dmel_CG1433
See related
AllianceGenome:FB:FBgn0019637
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
atu; CG1433; dLeo1; Dmel\CG1433; l(3)s1938; Leo1
Summary
Predicted to enable RNA polymerase II C-terminal domain phosphoserine binding activity. Involved in regulation of hemocyte proliferation. Predicted to be part of Cdc73/Paf1 complex. Predicted to be active in nucleus. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and mesoderm. Orthologous to human LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Atu in Genome Data Viewer
Location:
83B6-83B6; 3-47.5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5613358..5615939)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1439080..1441661)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene asterless Neighboring gene Antisense transcript of Rga Neighboring gene Regena Neighboring gene stable intronic sequence RNA 1 Neighboring gene antisense RNA:CR46135 Neighboring gene Spec2 Neighboring gene ncRNA Neighboring gene Diphthamide biosynthesis 4 Neighboring gene Ribosomal protein L13A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of the Paf1 complex in the maintenance of stem cell pluripotency and development. Park J, et al. FEBS J, 2023 Feb. PMID 35869661
  2. Parafibromin governs cell polarity and centrosome assembly in Drosophila neural stem cells. Deng Q, et al. PLoS Biol, 2022 Oct. PMID 36223339, Free PMC Article
  3. PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters. Gerlach JM, et al. Proc Natl Acad Sci U S A, 2017 Oct 31. PMID 29078288, Free PMC Article
  4. Regena (Rga), a Drosophila homolog of the global negative transcriptional regulator CDC36 (NOT2) from yeast, modifies gene expression and suppresses position effect variegation. Frolov MV, et al. Genetics, 1998 Jan. PMID 9475742, Free PMC Article
  5. Cytoplasmic polyadenylation element binding protein is a conserved target of tumor suppressor HRPT2/CDC73. Zhang JH, et al. Cell Death Differ, 2010 Oct. PMID 20339377, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA polymerase II C-terminal domain phosphoserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of hemocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Cdc73/Paf1 complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
another transcription unit
Names
Atu-PA
CG1433-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5613358..5615939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079516.3 → NP_524240.1  another transcription unit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524240.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94546, Q9VNE6
    Related
    FBpp0078353
    Conserved Domains (1) summary
    pfam04004
    Location:396 → 550
    Leo1; Leo1-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q94546.2 Q94546

Gene LinkOut

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