ube2na ubiquitin-conjugating enzyme E2Na [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ube2naprovided by ZNC
Official Full Name: ubiquitin-conjugating enzyme E2Naprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2873
See related: Ensembl:ENSDARG00000008748 AllianceGenome:ZFIN:ZDB-GENE-040426-2873
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ube2n; zgc:55726; wu:fb11b03; wu:fc08b06
Summary: Predicted to enable ubiquitin conjugating enzyme activity. Acts upstream of or within DNA damage response and protein polyubiquitination. Predicted to be active in nucleus. Orthologous to human UBE2N (ubiquitin conjugating enzyme E2 N). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (15778110..15793163)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (15809598..15824651)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fb11b03.x1 (e-PCR)
- UniSTS:190020

fb11b03.x1 (e-PCR)
- UniSTS:190021

fc08b06.x1 (e-PCR)
- UniSTS:192328

fb26a01.y1 (e-PCR)
- UniSTS:190372

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in postreplication repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K63-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein polyubiquitination	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2Na

Names: ube13a; ubiquitin-conjugating enzyme E2N

NP_998651.1

EC 6.3.2.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213486.1 → NP_998651.1 ubiquitin-conjugating enzyme E2Na

See identical proteins and their annotated locations for NP_998651.1

Status: PROVISIONAL

Source sequence(s)

BC044461

UniProtKB/TrEMBL

B2GQX1, Q803J2

Related

ENSDARP00000003705.5, ENSDART00000014188.7

Conserved Domains (1) summary

cl00154
Location:4 → 151

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...