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pank1a pantothenate kinase 1a [ Danio rerio (zebrafish) ]

Gene ID: 406789, updated on 4-Jan-2025

Summary

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Official Symbol
pank1aprovided by ZNC
Official Full Name
pantothenate kinase 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2846
See related
Ensembl:ENSDARG00000008192 AllianceGenome:ZFIN:ZDB-GENE-040426-2846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb79e08; zgc:63556; wu:fb79e08
Summary
Predicted to enable ATP binding activity and pantothenate kinase activity. Acts upstream of or within response to yeast. Is expressed in central nervous system and retina. Orthologous to human PANK1 (pantothenate kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See pank1a in Genome Data Viewer
Location:
chromosome: 17
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (23554900..23577017)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (23534859..23557620)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 7a Neighboring gene zgc:65997 Neighboring gene microRNA mir-107b Neighboring gene solute carrier family 16 member 12a Neighboring gene interferon-induced protein with tetratricopeptide repeats 16 Neighboring gene interferon-induced protein with tetratricopeptide repeats 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Bi-Allelic Mutations in Zebrafish pank2 Gene Lead to Testicular Atrophy and Perturbed Behavior without Signs of Neurodegeneration. Mignani L, et al. Int J Mol Sci, 2022 Oct 26. PMID 36361705, Free PMC Article
  2. Knock-down of pantothenate kinase 2 severely affects the development of the nervous and vascular system in zebrafish, providing new insights into PKAN disease. Zizioli D, et al. Neurobiol Dis, 2016 Jan. PMID 26476142, Free PMC Article
  3. miR-103/107 regulates left-right asymmetry in zebrafish by modulating Kupffer's vesicle development and ciliogenesis. Heigwer J, et al. Biochem Biophys Res Commun, 2020 Jun 25. PMID 32334837
  4. Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study. Wang YC, et al. BMC Syst Biol, 2013 Aug 16. PMID 23947337, Free PMC Article
  5. The zebrafish genes encoding the Polycomb repressive complex (PRC) 1. Le Faou P, et al. Gene, 2011 Apr 1. PMID 21195142

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables pantothenate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within coenzyme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to yeast IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
pantothenate kinase 1a
NP_998645.2
XP_005158562.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213480.2 → NP_998645.2  pantothenate kinase 1a

    Status: VALIDATED

    Source sequence(s)
    BX649437, CT954257
    UniProtKB/TrEMBL
    A0A8M1PFA2, F1QB40
    Related
    ENSDARP00000112870.1, ENSDART00000146787.3
    Conserved Domains (1) summary
    pfam03630
    Location:14 → 362
    Fumble; Fumble

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    23554900..23577017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158505.5 → XP_005158562.1  pantothenate kinase 1a isoform X1

    UniProtKB/TrEMBL
    A0A8M2B4X4
    Conserved Domains (1) summary
    pfam03630
    Location:80 → 428
    Fumble; Fumble

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394988.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    574767..593468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395331.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    140177..178683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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