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syt11a synaptotagmin XIa [ Danio rerio (zebrafish) ]

Gene ID: 406769, updated on 9-Dec-2024

Summary

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Official Symbol
syt11aprovided by ZNC
Official Full Name
synaptotagmin XIaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2815
See related
Ensembl:ENSDARG00000057913 AllianceGenome:ZFIN:ZDB-GENE-040426-2815
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
syt11; fc52d10; fi68d01; zgc:55556; wu:fc52d10; wu:fi68d01
Summary
Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in calcium-dependent activation of synaptic vesicle fusion; regulation of calcium ion-dependent exocytosis; and vesicle fusion. Predicted to be located in membrane. Predicted to be active in several cellular components, including axon; exocytic vesicle; and synapse. Is expressed in nervous system; neural tube; and trigeminal placode. Orthologous to human SYT11 (synaptotagmin 11). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See syt11a in Genome Data Viewer
Location:
chromosome: 19
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (23982416..24032417)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (24398193..24448194)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene SNAP associated protein Neighboring gene SMAD family member 10a Neighboring gene Ras-like without CAAX 1 Neighboring gene peroxisomal biogenesis factor 11 beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans. Craxton M. BMC Genomics, 2007 Jul 31. PMID 17672888, Free PMC Article
  2. Synaptotagmin gene content of the sequenced genomes. Craxton M. BMC Genomics, 2004 Jul 6. PMID 15238157, Free PMC Article
  3. Single-cell transcriptomic analysis of neuroepithelial cells and other cell types of the gills of zebrafish (Danio rerio) exposed to hypoxia. Pan W, et al. Sci Rep, 2022 Jun 16. PMID 35710785, Free PMC Article
  4. Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas. Liu Z, et al. J Biol Chem, 2011 Aug 12. PMID 21669877, Free PMC Article
  5. A manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes--an open access resource for neuroscience and evolutionary biology. Craxton M. BMC Genomics, 2010 Jan 15. PMID 20078875, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion sensor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium-dependent activation of synaptic vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
synaptotagmin-11a
Names
synaptotagmin XI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213460.2 → NP_998625.2  synaptotagmin-11a

    Status: VALIDATED

    Source sequence(s)
    BX548249
    UniProtKB/TrEMBL
    A0A8M1PJG8, F1RD06
    Related
    ENSDARP00000075119.5, ENSDART00000080673.6
    Conserved Domains (2) summary
    cd08404
    Location:312 → 449
    C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4
    cl14603
    Location:179 → 290
    C2; C2 domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    23982416..24032417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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