capn1 calpain 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: capn1provided by ZNC
Official Full Name: calpain 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2814
See related: Ensembl:ENSDARG00000045199 AllianceGenome:ZFIN:ZDB-GENE-040426-2814
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj67g01; zgc:55262; wu:fj67g01
Summary: Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; intermediate cell mass of mesoderm; musculature system; sensory system; and solid lens vesicle. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 76. Orthologous to human CAPN1 (calpain 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (6684131..6753886, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (6548433..6618188, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G46219 (e-PCR)
- UniSTS:107021

G44991 (e-PCR)
- UniSTS:105793

fj67g01.x1 (e-PCR)
- UniSTS:188772

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: calpain-1 catalytic subunit

NP_998624.1

EC 3.4.22.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213459.1 → NP_998624.1 calpain-1 catalytic subunit

See identical proteins and their annotated locations for NP_998624.1

Status: PROVISIONAL

Source sequence(s)

BC048025

UniProtKB/TrEMBL

Q7ZUR1

Related

ENSDARP00000102675.1, ENSDART00000113658.4

Conserved Domains (6) summary

cd00051
Location:580 → 634

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00648
Location:51 → 347

Peptidase_C2; Calpain family cysteine protease

pfam01067
Location:361 → 509

Calpain_III; Calpain large subunit, domain III

pfam13499
Location:612 → 698

EF-hand_7; EF-hand domain pair

pfam13833
Location:547 → 606

EF-hand_8; EF-hand domain pair

cl08302
Location:613 → 692

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...