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sass6 SAS-6 centriolar assembly protein [ Danio rerio (zebrafish) ]

Gene ID: 406747, updated on 4-Jan-2025

Summary

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Official Symbol
sass6provided by ZNC
Official Full Name
SAS-6 centriolar assembly proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2784
See related
Ensembl:ENSDARG00000058346 AllianceGenome:ZFIN:ZDB-GENE-040426-2784
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55668; wu:fb98c12
Summary
Acts upstream of or within several processes, including embryonic cleavage; microtubule cytoskeleton organization; and spermatogenesis. Located in centrosome. Is expressed in blastomere and unfertilized egg. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 14. Orthologous to human SASS6 (SAS-6 centriolar assembly protein). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See sass6 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (10735909..10752315, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (10706227..10722597, complement)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 14A Neighboring gene major facilitator superfamily domain containing 14A 1 Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene transmembrane serine protease 9 Neighboring gene translocase of inner mitochondrial membrane 13 homolog (yeast)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Structures of SAS-6 suggest its organization in centrioles. van Breugel M, et al. Science, 2011 Mar 4. PMID 21273447
  2. The zebrafish maternal-effect gene cellular atoll encodes the centriolar component sas-6 and defects in its paternal function promote whole genome duplication. Yabe T, et al. Dev Biol, 2007 Dec 1. PMID 17950723, Free PMC Article
  3. In vitro oocyte culture-based manipulation of zebrafish maternal genes. Nair S, et al. Dev Dyn, 2013 Jan. PMID 23074011, Free PMC Article
  4. Maternal control of vertebrate development before the midblastula transition: mutants from the zebrafish I. Dosch R, et al. Dev Cell, 2004 Jun. PMID 15177026
  5. The zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organization. Pfaff KL, et al. Mol Cell Biol, 2007 Aug. PMID 17576815, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cea encodes the centriolar coiled-coil protein Sas-6, and that zebrafish Cea/Sas-6 protein localizes to centrosomes.[Cea]
    Title: The zebrafish maternal-effect gene cellular atoll encodes the centriolar component sas-6 and defects in its paternal function promote whole genome duplication.
  2. study determined the x-ray structure of the amino-terminal domain of SAS-6 and showed that recombinant SAS-6 self-associates in vitro into assemblies that resemble cartwheel centers
    Title: Structures of SAS-6 suggest its organization in centrioles.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centriole replication ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within centrosome duplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic cleavage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in deuterosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
spindle assembly abnormal protein 6 homolog
Names
cea
cellular atoll
spindle assembly 6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213438.1 → NP_998603.1  spindle assembly abnormal protein 6 homolog

    See identical proteins and their annotated locations for NP_998603.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045420
    UniProtKB/Swiss-Prot
    Q7ZVT3
    UniProtKB/TrEMBL
    B2GRL0
    Related
    ENSDARP00000075634.5, ENSDART00000081191.6
    Conserved Domains (2) summary
    COG1340
    Location:215 → 472
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    pfam16531
    Location:46 → 140
    SAS-6_N; Centriolar protein SAS N-terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    10735909..10752315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068216275.1 → XP_068072376.1  spindle assembly abnormal protein 6 homolog isoform X5

  2. XM_009296095.4 → XP_009294370.1  spindle assembly abnormal protein 6 homolog isoform X4

    UniProtKB/TrEMBL
    A0A8M3AM46
    Conserved Domains (1) summary
    pfam16531
    Location:46 → 140
    SAS-6_N; Centriolar protein SAS N-terminal

  3. XM_068216274.1 → XP_068072375.1  spindle assembly abnormal protein 6 homolog isoform X3

  4. XM_068216273.1 → XP_068072374.1  spindle assembly abnormal protein 6 homolog isoform X2

  5. XM_005173944.5 → XP_005174001.1  spindle assembly abnormal protein 6 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8M2BL83
    Conserved Domains (2) summary
    COG1340
    Location:215 → 472
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    pfam16531
    Location:46 → 140
    SAS-6_N; Centriolar protein SAS N-terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZVT3.1 GenPept UniProtKB/Swiss-Prot:Q7ZVT3

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