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exoc7 exocyst complex component 7 [ Danio rerio (zebrafish) ]

Gene ID: 406723, updated on 9-Dec-2024

Summary

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Official Symbol
exoc7provided by ZNC
Official Full Name
exocyst complex component 7provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2752
See related
Ensembl:ENSDARG00000087229 AllianceGenome:ZFIN:ZDB-GENE-040426-2752
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56575
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Involved in telencephalon development. Predicted to be part of exocyst. Used to study microcephaly. Orthologous to human EXOC7 (exocyst complex component 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See exoc7 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (46696868..46738403)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (46703660..46745179)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 16 Neighboring gene trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) Neighboring gene plasminogen activator, urokinase b Neighboring gene vinculin b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Regulation of human cerebral cortical development by EXOC7 and EXOC8, components of the exocyst complex, and roles in neural progenitor cell proliferation and survival. Coulter ME, et al. Genet Med, 2020 Jun. PMID 32103185, Free PMC Article
  2. Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations. Goudarzi M, et al. Dev Cell, 2017 Dec 4. PMID 29173819, Free PMC Article
  3. Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Shim H, et al. Nucleic Acids Res, 2016 Nov 16. PMID 27903883, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in telencephalon development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exocyst IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
exocyst complex component 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213414.1 → NP_998579.1  exocyst complex component 7

    See identical proteins and their annotated locations for NP_998579.1

    Status: PROVISIONAL

    Source sequence(s)
    BC052121
    UniProtKB/Swiss-Prot
    E7FC72
    UniProtKB/TrEMBL
    Q7ZTX5
    Related
    ENSDARP00000106499.1, ENSDART00000123357.4
    Conserved Domains (1) summary
    pfam03081
    Location:308 → 667
    Exo70; Exo70 exocyst complex subunit

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    46696868..46738403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005172976.5 → XP_005173033.1  exocyst complex component 7 isoform X1

    UniProtKB/Swiss-Prot
    E7FC72
    UniProtKB/TrEMBL
    A0A286Y9B1, A0A8M2BKR1
    Related
    ENSDARP00000143777.1, ENSDART00000174765.2
    Conserved Domains (1) summary
    pfam03081
    Location:321 → 693
    Exo70; Exo70 exocyst complex subunit

  2. XM_005172978.5 → XP_005173035.1  exocyst complex component 7 isoform X4

    UniProtKB/Swiss-Prot
    E7FC72
    UniProtKB/TrEMBL
    A0A8M2BK81
    Conserved Domains (1) summary
    pfam03081
    Location:321 → 680
    Exo70; Exo70 exocyst complex subunit

  3. XM_009306982.4 → XP_009305257.1  exocyst complex component 7 isoform X3

    UniProtKB/Swiss-Prot
    E7FC72
    UniProtKB/TrEMBL
    A0A8M3AYR4
    Conserved Domains (1) summary
    pfam03081
    Location:312 → 684
    Exo70; Exo70 exocyst complex subunit

  4. XM_021480048.2 → XP_021335723.1  exocyst complex component 7 isoform X7

    UniProtKB/Swiss-Prot
    E7FC72
    UniProtKB/TrEMBL
    A0A8M9Q897
    Conserved Domains (1) summary
    pfam03081
    Location:312 → 671
    Exo70; Exo70 exocyst complex subunit

  5. XM_009306981.4 → XP_009305256.1  exocyst complex component 7 isoform X2

    UniProtKB/Swiss-Prot
    E7FC72
    UniProtKB/TrEMBL
    A0A8M3B4X1, U3JAX5
    Related
    ENSDARP00000127396.1, ENSDART00000152928.3
    Conserved Domains (1) summary
    pfam03081
    Location:317 → 689
    Exo70; Exo70 exocyst complex subunit

  6. XM_005172980.5 → XP_005173037.1  exocyst complex component 7 isoform X6

    UniProtKB/Swiss-Prot
    E7FC72
    UniProtKB/TrEMBL
    A0A8M2BK84, U3JB38
    Related
    ENSDARP00000127460.1, ENSDART00000152880.3
    Conserved Domains (1) summary
    pfam03081
    Location:317 → 676
    Exo70; Exo70 exocyst complex subunit

  7. XM_005172979.5 → XP_005173036.1  exocyst complex component 7 isoform X5

    UniProtKB/Swiss-Prot
    E7FC72
    UniProtKB/TrEMBL
    A0A8M2BKA5
    Conserved Domains (1) summary
    pfam03081
    Location:308 → 680
    Exo70; Exo70 exocyst complex subunit

  8. XM_005172981.5 → XP_005173038.1  exocyst complex component 7 isoform X8

    UniProtKB/Swiss-Prot
    E7FC72
    UniProtKB/TrEMBL
    A0A8M2BKR2
    Conserved Domains (1) summary
    pfam03081
    Location:287 → 659
    Exo70; Exo70 exocyst complex subunit

  9. XM_005172982.5 → XP_005173039.1  exocyst complex component 7 isoform X9

    UniProtKB/Swiss-Prot
    E7FC72
    UniProtKB/TrEMBL
    A0A8M2BK98, U3JAN6
    Related
    ENSDARP00000127304.1, ENSDART00000153445.3
    Conserved Domains (1) summary
    pfam03081
    Location:287 → 646
    Exo70; Exo70 exocyst complex subunit

  10. XM_068224536.1 → XP_068080637.1  exocyst complex component 7 isoform X10

    UniProtKB/Swiss-Prot
    E7FC72
    Related
    ENSDARP00000106414.2, ENSDART00000123834.3

  11. XM_005172977.5 → XP_005173034.1  exocyst complex component 7 isoform X11

    UniProtKB/Swiss-Prot
    E7FC72
    UniProtKB/TrEMBL
    A0A2R8QNA9, A0A8M2BK85
    Related
    ENSDARP00000156036.1, ENSDART00000189923.1
    Conserved Domains (1) summary
    pfam03081
    Location:338 → 697
    Exo70; Exo70 exocyst complex subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E7FC72.2 GenPept UniProtKB/Swiss-Prot:E7FC72

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