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rap1ab RAP1A, member of RAS oncogene family b [ Danio rerio (zebrafish) ]

Gene ID: 406714, updated on 4-Jan-2025

Summary

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Official Symbol
rap1abprovided by ZNC
Official Full Name
RAP1A, member of RAS oncogene family bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2738
See related
Ensembl:ENSDARG00000087346 AllianceGenome:ZFIN:ZDB-GENE-040426-2738
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56630
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Acts upstream of or within convergent extension involved in gastrulation and embryonic cranial skeleton morphogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human RAP1A (RAP1A, member of RAS oncogene family). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See rap1ab in Genome Data Viewer
Location:
chromosome: 11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (15833565..15875054, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (15698642..15740419, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene growth differentiation factor 11 Neighboring gene uncharacterized LOC137490700 Neighboring gene uncharacterized LOC137496681 Neighboring gene pantothenate kinase 4 (inactive) Neighboring gene dorsal inhibitory axon guidance protein a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Small molecule inhibition of RAS/MAPK signaling ameliorates developmental pathologies of Kabuki Syndrome. Tsai IC, et al. Sci Rep, 2018 Jul 17. PMID 30018450, Free PMC Article
  2. RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome. Bögershausen N, et al. J Clin Invest, 2015 Sep. PMID 26280580, Free PMC Article
  3. Rap1b Promotes Notch-Signal-Mediated Hematopoietic Stem Cell Development by Enhancing Integrin-Mediated Cell Adhesion. Rho SS, et al. Dev Cell, 2019 Jun 3. PMID 31006651
  4. Dual role of Jam3b in early hematopoietic and vascular development. Kobayashi I, et al. Development, 2020 Jan 8. PMID 31852685
  5. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Rap protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Rap protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to cAMP IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within convergent extension involved in gastrulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-related protein rap1ab
Names
ras-related protein Rap-1b-like
NP_001230108.1
NP_998570.2
XP_021335265.1
XP_068080240.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243179.1 → NP_001230108.1  ras-related protein rap1ab

    See identical proteins and their annotated locations for NP_001230108.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    EH543099, FP003590
    UniProtKB/TrEMBL
    A0A8M1PJC7, E7FBI4
    Related
    ENSDARP00000130669.1, ENSDART00000165836.3
    Conserved Domains (1) summary
    cd04175
    Location:3 → 167
    Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

  2. NM_213405.2 → NP_998570.2  ras-related protein rap1ab

    See identical proteins and their annotated locations for NP_998570.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    FP003590
    UniProtKB/TrEMBL
    A0A8M1PJC7, E7FBI4
    Related
    ENSDARP00000110237.1, ENSDART00000129526.3
    Conserved Domains (1) summary
    cd04175
    Location:3 → 167
    Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    15833565..15875054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479590.2 → XP_021335265.1  ras-related protein rap1ab isoform X1

    UniProtKB/TrEMBL
    A0A8M1PJC7, E7FBI4
    Conserved Domains (1) summary
    cd04175
    Location:3 → 167
    Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

  2. XM_068224139.1 → XP_068080240.1  ras-related protein rap1ab isoform X1

    UniProtKB/TrEMBL
    A0A8M1PJC7, E7FBI4

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394809.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    6282..47771 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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