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vrk1 VRK serine/threonine kinase 1 [ Danio rerio (zebrafish) ]

Gene ID: 406694, updated on 9-Dec-2024

Summary

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Official Symbol
vrk1provided by ZNC
Official Full Name
VRK serine/threonine kinase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2709
See related
Ensembl:ENSDARG00000018006 AllianceGenome:ZFIN:ZDB-GENE-040426-2709
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56266; wu:fe16f06
Summary
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within neural precursor cell proliferation and spermatogenesis. Predicted to be located in Golgi stack. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 10 and pontocerebellar hypoplasia type 1A. Orthologous to human VRK1 (VRK serine/threonine kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See vrk1 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (18773961..18797223, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (18754125..18777387, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488089 Neighboring gene uncharacterized LOC110438037 Neighboring gene si:dkey-288a3.2 Neighboring gene adenylate kinase 7b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Ankle2 deficiency-associated microcephaly and spermatogenesis defects in zebrafish are alleviated by heterozygous deletion of vrk1. Apridita Sebastian W, et al. Biochem Biophys Res Commun, 2022 Oct 8. PMID 35940133
  2. Behavioral and neurological effects of Vrk1 deficiency in zebrafish. Carrasco Apolinario ME, et al. Biochem Biophys Res Commun, 2023 Oct 1. PMID 37429068
  3. Vrk2 deficiency elicits aggressive behavior in female zebrafish. Umeda R, et al. Genes Cells, 2022 Apr. PMID 35094457
  4. Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development. Yu WX, et al. Cell Death Discov, 2022 Dec 13. PMID 36513626, Free PMC Article
  5. Comparative analysis of single-cell transcriptomics in human and Zebrafish oocytes. Can H, et al. BMC Genomics, 2020 Jul 8. PMID 32640983, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Behavioral and neurological effects of Vrk1 deficiency in zebrafish.
    Title: Behavioral and neurological effects of Vrk1 deficiency in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in Golgi disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neural precursor cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein localization to chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Cajal body IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi stack ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase VRK1
Names
vaccinia related kinase 1
NP_998550.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213385.1 → NP_998550.1  serine/threonine-protein kinase VRK1

    See identical proteins and their annotated locations for NP_998550.1

    Status: PROVISIONAL

    Source sequence(s)
    BC047853
    UniProtKB/Swiss-Prot
    Q7ZUS1
    Related
    ENSDARP00000045990.6, ENSDART00000045991.7
    Conserved Domains (3) summary
    COG0515
    Location:37 → 265
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    pfam06217
    Location:373 → 424
    GAGA_bind; GAGA binding protein-like family
    cl21453
    Location:27 → 327
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    18773961..18797223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZUS1.1 GenPept UniProtKB/Swiss-Prot:Q7ZUS1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.