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srsf2a serine and arginine rich splicing factor 2a [ Danio rerio (zebrafish) ]

Gene ID: 406691, updated on 4-Jan-2025

Summary

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Official Symbol
srsf2aprovided by ZNC
Official Full Name
serine and arginine rich splicing factor 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2706
See related
Ensembl:ENSDARG00000057484 AllianceGenome:ZFIN:ZDB-GENE-040426-2706
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sfrs2; srsf2; zgc:56283; hm:zeh0252; wu:fb51a05; wu:fk59b08
Summary
Predicted to enable RNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in nuclear speck. Human ortholog(s) of this gene implicated in acute myeloid leukemia; congestive heart failure; hepatocellular carcinoma; and myelodysplastic syndrome. Orthologous to several human genes including SRSF2 (serine and arginine rich splicing factor 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See srsf2a in Genome Data Viewer
Location:
chromosome: 12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (31720672..31724380, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (31605768..31609565, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene dynamin binding protein Neighboring gene hyaluronan binding protein 2 Neighboring gene ring finger protein 157 Neighboring gene 5-hydroxytryptamine receptor 3A-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2. Soto RA, et al. Stem Cell Reports, 2021 Jul 13. PMID 34143974, Free PMC Article
  2. Number of inadvertent RNA targets for morpholino knockdown in Danio rerio is largely underestimated: evidence from the study of Ser/Arg-rich splicing factors. Joris M, et al. Nucleic Acids Res, 2017 Sep 19. PMID 28934490, Free PMC Article
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine and arginine rich splicing factor 2a
Names
serine/arginine-rich splicing factor 2
serine/arginine-rich splicing factor 2a
splicing factor, arginine/serine-rich 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213382.1 → NP_998547.1  serine and arginine rich splicing factor 2a

    See identical proteins and their annotated locations for NP_998547.1

    Status: PROVISIONAL

    Source sequence(s)
    BC046045
    UniProtKB/TrEMBL
    A0A8M1PGY9, Q7ZV13
    Related
    ENSDARP00000074623.4, ENSDART00000080173.6
    Conserved Domains (2) summary
    COG0724
    Location:5 → 91
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12311
    Location:16 → 88
    RRM_SRSF2_SRSF8; RNA recognition motif in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    31720672..31724380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_222035.5 RNA Sequence

    Related
    ENSDART00000153102.3
Nucleotide Protein Strain
Heading Accession and Version

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