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Snm1 Snm1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40669, updated on 9-Dec-2024

Summary

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Official Symbol
Snm1provided by FlyBase
Official Full Name
Snm1provided by FlyBase
Primary source
FLYBASE:FBgn0037338
Locus tag
Dmel_CG10018
See related
AllianceGenome:FB:FBgn0037338
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10018; Dmel\CG10018; mus322; SNM1
Summary
Predicted to enable 5'-3' DNA exonuclease activity and damaged DNA binding activity. Predicted to be involved in double-strand break repair via nonhomologous end joining and interstrand cross-link repair. Is expressed in organism and spermatozoon. Orthologous to human DCLRE1A (DNA cross-link repair 1A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Snm1 in Genome Data Viewer
Location:
83B1-83B2; 3-47.5 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5555084..5557786)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1380806..1383508)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene meiosis I arrest Neighboring gene Protein-L-isoaspartate (D-aspartate) O-methyltransferase Neighboring gene Phosphatidylinositol 4-kinase II alpha Neighboring gene ncRNA Neighboring gene antisense RNA:CR46136

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A large-scale screen for mutagen-sensitive loci in Drosophila. Laurencon A, et al. Genetics, 2004 May. PMID 15166149, Free PMC Article
  2. DNA Repair in Drosophila: Mutagens, Models, and Missing Genes. Sekelsky J. Genetics, 2017 Feb. PMID 28154196, Free PMC Article
  3. The Adaptive Significance of Natural Genetic Variation in the DNA Damage Response of Drosophila melanogaster. Svetec N, et al. PLoS Genet, 2016 Mar. PMID 26950216, Free PMC Article
  4. A genetic screen and transcript profiling reveal a shared regulatory program for Drosophila linker histone H1 and chromatin remodeler CHD1. Kavi H, et al. G3 (Bethesda), 2015 Jan 27. PMID 25628309, Free PMC Article
  5. Protein interaction mapping: a Drosophila case study. Formstecher E, et al. Genome Res, 2005 Mar. PMID 15710747, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 5'-3' DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Snm1
Names
CG10018-PA
Snm1-PA
mutagen-sensitive 322

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5555084..5557786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141291.4 → NP_649548.1  Snm1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649548.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VND2
    Related
    FBpp0078337
    Conserved Domains (2) summary
    pfam07522
    Location:481 → 578
    DRMBL; DNA repair metallo-beta-lactamase
    cd16273
    Location:252 → 408
    SNM1A-1C-like_MBL-fold; SNM1A , artemis/SNM1C, yeast Pso2p, and related proteins; MBL-fold metallo-hydrolase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VND2 Q9VND2

Gene LinkOut

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