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uba2 ubiquitin-like modifier activating enzyme 2 [ Danio rerio (zebrafish) ]

Gene ID: 406672, updated on 9-Dec-2024

Summary

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Official Symbol
uba2provided by ZNC
Official Full Name
ubiquitin-like modifier activating enzyme 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2681
See related
Ensembl:ENSDARG00000101332 AllianceGenome:ZFIN:ZDB-GENE-040426-2681
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sae2; sae2b; uble1b; zgc:66354; wu:fi17g06
Summary
Predicted to enable SUMO activating enzyme activity. Acts upstream of or within several processes, including fin morphogenesis; regulation of cartilage development; and regulation of neural retina development. Predicted to be located in nucleus. Predicted to be part of SUMO activating enzyme complex. Predicted to be active in cytoplasm. Is expressed in forebrain neural rod; head; nervous system; pectoral fin bud; and somite. Orthologous to human UBA2 (ubiquitin like modifier activating enzyme 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See uba2 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (12811315..12824635, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (12714915..12728135, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 member 5 Neighboring gene carbonic anhydrase Va Neighboring gene chemokine (C-C motif) ligand 33, duplicate 3 Neighboring gene chemokine (C-C motif) ligand 33, duplicate 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. UBA2 variants underlie a recognizable syndrome with variable aplasia cutis congenita and ectrodactyly. Schnur RE, et al. Genet Med, 2021 Sep. PMID 34040189, Free PMC Article
  2. Parp inhibition prevents ten-eleven translocase enzyme activation and hyperglycemia-induced DNA demethylation. Dhliwayo N, et al. Diabetes, 2014 Sep. PMID 24722243, Free PMC Article
  3. Insights into the evolution of the ISG15 and UBA7 system. Liu S, et al. Genomics, 2022 Mar. PMID 35134494
  4. Chemokine C-C motif ligand 33 is a key regulator of teleost fish barbel development. Zhou T, et al. Proc Natl Acad Sci U S A, 2018 May 29. PMID 29760055, Free PMC Article
  5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables SUMO activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO activating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables SUMO activating enzyme activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables aminoacyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like modifier activating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fin morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein sumoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein sumoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein sumoylation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of cartilage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of neural retina development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SUMO activating enzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SUMO activating enzyme complex IEA
Inferred from Electronic Annotation
more info
  
part_of SUMO activating enzyme complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SUMO-activating enzyme subunit 2
Names
SUMO1 activating enzyme subunit 2
SUMO1 activating enzyme subunit 2b
ubiquitin-like 1 (sentrin) activating enzyme E1B
ubiquitin-like 1-activating enzyme E1B
NP_998528.1
XP_009296132.1
XP_009296133.1
XP_068073455.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213363.1 → NP_998528.1  SUMO-activating enzyme subunit 2

    See identical proteins and their annotated locations for NP_998528.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055614
    UniProtKB/Swiss-Prot
    A7MCK7, B0S543, B0S544, Q7SXG4
    UniProtKB/TrEMBL
    B2GQ09
    Related
    ENSDARP00000130924.1, ENSDART00000169126.2
    Conserved Domains (5) summary
    cd01489
    Location:20 → 439
    Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    pfam00899
    Location:16 → 176
    ThiF; ThiF family
    pfam10585
    Location:180 → 357
    UBA_e1_thiolCys; Ubiquitin-activating enzyme active site
    pfam14732
    Location:447 → 533
    UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
    pfam16195
    Location:544 → 628
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    12811315..12824635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068217354.1 → XP_068073455.1  SUMO-activating enzyme subunit 2 isoform X3

    UniProtKB/Swiss-Prot
    A7MCK7, B0S543, B0S544, Q7SXG4

  2. XM_009297858.4 → XP_009296133.1  SUMO-activating enzyme subunit 2 isoform X2

    UniProtKB/Swiss-Prot
    A7MCK7, B0S543, B0S544, Q7SXG4
    UniProtKB/TrEMBL
    A0A8M3ANZ0
    Conserved Domains (5) summary
    cd01489
    Location:20 → 440
    Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    pfam00899
    Location:16 → 176
    ThiF; ThiF family
    pfam10585
    Location:180 → 358
    UBA_e1_thiolCys; Ubiquitin-activating enzyme active site
    pfam14732
    Location:448 → 534
    UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
    pfam16195
    Location:545 → 628
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus

  3. XM_009297857.4 → XP_009296132.1  SUMO-activating enzyme subunit 2 isoform X1

    UniProtKB/Swiss-Prot
    A7MCK7, B0S543, B0S544, Q7SXG4
    UniProtKB/TrEMBL
    A0A8M3AWE5
    Conserved Domains (5) summary
    cd01489
    Location:20 → 440
    Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    pfam00899
    Location:16 → 176
    ThiF; ThiF family
    pfam10585
    Location:180 → 358
    UBA_e1_thiolCys; Ubiquitin-activating enzyme active site
    pfam14732
    Location:448 → 534
    UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
    pfam16195
    Location:545 → 629
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395190.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    117484..136943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7SXG4.2 GenPept UniProtKB/Swiss-Prot:Q7SXG4

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