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rhoac ras homolog gene family, member Ac [ Danio rerio (zebrafish) ]

Gene ID: 406659, updated on 9-Dec-2024

Summary

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Official Symbol
rhoacprovided by ZNC
Official Full Name
ras homolog gene family, member Acprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2665
See related
Ensembl:ENSDARG00000116058 AllianceGenome:ZFIN:ZDB-GENE-040426-2665
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:63939; wu:fc17g01
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including skeletal muscle satellite cell migration; stress fiber assembly; and wound healing, spreading of cells. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be located in membrane. Predicted to be active in cleavage furrow; cytosol; and dendritic spine. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (ras homolog family member A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See rhoac in Genome Data Viewer
Location:
chromosome: 23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (903019..912590, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (893899..903470, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene FERM domain containing 4Bb Neighboring gene uncharacterized LOC137489064 Neighboring gene RNA binding motif protein 10 Neighboring gene desmocollin-2-like Neighboring gene cadherin 26, tandem duplicate 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection. Salas-Vidal E, et al. Genomics, 2005 Jul. PMID 15894457
  2. Tissue Extract Fractions from Starfish Undergoing Regeneration Promote Wound Healing and Lower Jaw Blastema Regeneration of Zebrafish. Dai Y, et al. Sci Rep, 2016 Dec 15. PMID 27974833, Free PMC Article
  3. Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components. van der Sar AM, et al. Mol Immunol, 2009 Jul. PMID 19409617
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle satellite cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in wound healing, spreading of cells ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho-related GTP-binding protein RhoA-C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213350.1 → NP_998515.1  rho-related GTP-binding protein RhoA-C

    See identical proteins and their annotated locations for NP_998515.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054576
    UniProtKB/Swiss-Prot
    F1R5L0, Q7T2E8
    Related
    ENSDARP00000151463.1, ENSDART00000192851.1
    Conserved Domains (2) summary
    smart00174
    Location:8 → 181
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd01870
    Location:5 → 179
    RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    903019..912590 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7T2E8.1 GenPept UniProtKB/Swiss-Prot:Q7T2E8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.