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aimp2 aminoacyl tRNA synthetase complex interacting multifunctional protein 2 [ Danio rerio (zebrafish) ]

Gene ID: 406647, updated on 9-Dec-2024

Summary

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Official Symbol
aimp2provided by ZNC
Official Full Name
aminoacyl tRNA synthetase complex interacting multifunctional protein 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2652
See related
Ensembl:ENSDARG00000018903 AllianceGenome:ZFIN:ZDB-GENE-040426-2652
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:63976; wu:fc09d04
Summary
Predicted to act upstream of or within apoptotic process and cell differentiation. Predicted to be located in cytosol and nucleus. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alar plate midbrain region; brain; digestive system; immature eye; and pectoral fin. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 17. Orthologous to human AIMP2 (aminoacyl tRNA synthetase complex interacting multifunctional protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See aimp2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (61108356..61116295, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (60875768..60883670, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, gamma subunit 1b Neighboring gene calcium channel, voltage-dependent, gamma subunit 4b Neighboring gene parvalbumin 8 Neighboring gene parvalbumin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Systematic expression profiling of neuropathy-related aminoacyl-tRNA synthetases in zebrafish during development. Giong HK, et al. Biochem Biophys Res Commun, 2022 Jan 8. PMID 34872004
  2. Biallelic variants in KARS1 are associated with neurodevelopmental disorders and hearing loss recapitulated by the knockout zebrafish. Lin SJ, et al. Genet Med, 2021 Oct. PMID 34172899, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of aminoacyl-tRNA synthetase multienzyme complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aminoacyl tRNA synthase complex-interacting multifunctional protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213338.1 → NP_998503.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2

    See identical proteins and their annotated locations for NP_998503.1

    Status: PROVISIONAL

    Source sequence(s)
    BC053178
    UniProtKB/TrEMBL
    Q7T3C0
    Related
    ENSDARP00000008898.5, ENSDART00000009194.8
    Conserved Domains (2) summary
    cd03200
    Location:215 → 310
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
    pfam16780
    Location:1 → 31
    AIMP2_LysRS_bd; AIMP2 lysyl-tRNA synthetase binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    61108356..61116295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470105.2 → XP_021325780.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PXA5
    Related
    ENSDARP00000129634.1, ENSDART00000156978.2
    Conserved Domains (1) summary
    cd03200
    Location:179 → 274
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
Nucleotide Protein Strain
Heading Accession and Version

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