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Itpr - Inositol 1,4,5,-trisphosphate receptor

Enables inositol 1,4,5-trisphosphate-gated calcium channel activity. Involved in several processes, including autophagic cell death; cellular response to ethanol; and fatty acid homeostasis. Located in axonal growth cone and smooth endoplasmic reticulum. Is expressed in several structures, including imaginal disc; organism subdivision; sense organ; sensory organ cell; and somatic muscle cell. Used to study autosomal dominant cerebellar ataxia and obesity. Human ortholog(s) of this gene implicated in several diseases, including Gillespie syndrome; amyotrophic lateral sclerosis; autosomal dominant cerebellar ataxia (multiple); isolated anhidrosis with normal sweat glands; and type 1 diabetes mellitus. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1); ITPR2 (inositol 1,4,5-trisphosphate receptor type 2); and ITPR3 (inositol 1,4,5-trisphosphate receptor type 3). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa