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RpL35A Ribosomal protein L35A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40654, updated on 9-Dec-2024

Summary

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Official Symbol
RpL35Aprovided by FlyBase
Official Full Name
Ribosomal protein L35Aprovided by FlyBase
Primary source
FLYBASE:FBgn0037328
Locus tag
Dmel_CG2099
See related
AllianceGenome:FB:FBgn0037328
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey39; CG2099; Dmel\CG2099; L33e; L35a; Rp L35A; Rpl35A
Summary
A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation and ribosomal large subunit biogenesis. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 5. Orthologous to human RPL35A (ribosomal protein L35a). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See RpL35A in Genome Data Viewer
Location:
83A4-83A4; 3-47.5 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5465630..5467101, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1291352..1292823, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pancreatic eIF-2alpha kinase Neighboring gene Polymerase (DNA-directed), delta interacting protein 2 Neighboring gene mitochondrial ribosomal protein L44 Neighboring gene Snf5-related 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Population suppression with dominant female-lethal alleles is boosted by homing gene drive. Zhu J, et al. BMC Biol, 2024 Sep 11. PMID 39256812, Free PMC Article
  2. A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population. Champer J, et al. Proc Natl Acad Sci U S A, 2020 Sep 29. PMID 32929034, Free PMC Article
  3. Assessment of distant-site rescue elements for CRISPR toxin-antidote gene drives. Chen J, et al. Front Bioeng Biotechnol, 2023. PMID 36860883, Free PMC Article
  4. Experimental demonstration of tethered gene drive systems for confined population modification or suppression. Metzloff M, et al. BMC Biol, 2022 May 24. PMID 35606745, Free PMC Article
  5. Local Microtubule and F-Actin Distributions Fully Constrain the Spatial Geometry of Drosophila Sensory Dendritic Arbors. Nanda S, et al. Int J Mol Sci, 2023 Apr 4. PMID 37047715, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables structural constituent of ribosome HDA PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation TAS
Traceable Author Statement
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosolic ribosome HDA PubMed 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal protein L35A
Names
CG2099-PA
RpL35A-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5465630..5467101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141282.3 → NP_649539.1  ribosomal protein L35A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649539.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNB9
    Related
    FBpp0078416
    Conserved Domains (1) summary
    pfam01247
    Location:50 → 150
    Ribosomal_L35Ae; Ribosomal protein L35Ae
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VNB9 Q9VNB9

Gene LinkOut

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