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CG12147 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40651, updated on 9-Dec-2024

Summary

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Official Symbol
CG12147provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037325
Locus tag
Dmel_CG12147
See related
AllianceGenome:FB:FBgn0037325
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CKIalpha like; CKIalpha-like II; Dmel\CG12147
Summary
Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including endocytosis; positive regulation of canonical Wnt signaling pathway; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cytoplasm. Orthologous to human CSNK1A1 (casein kinase 1 alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG12147 in Genome Data Viewer
Location:
83A2-83A2; 3-47.5 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5425369..5427257, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1251091..1252979, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Odorant receptor co-receptor Neighboring gene uncharacterized protein Neighboring gene pancreatic eIF-2alpha kinase Neighboring gene Ribosomal protein L35A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolution of casein kinase 1 and functional analysis of new doubletime mutants in Drosophila. Thakkar N, et al. Front Physiol, 2022. PMID 36589447, Free PMC Article
  2. Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1. Meng Z, et al. Mol Biol Cell, 2011 Aug 15. PMID 21680713, Free PMC Article
  3. Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Jia J, et al. Dev Cell, 2005 Dec. PMID 16326393
  4. Regulation of wingless signaling by the CKI family in Drosophila limb development. Zhang L, et al. Dev Biol, 2006 Nov 1. PMID 16987508, Free PMC Article
  5. Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling. Serysheva E, et al. EMBO Rep, 2013 Aug. PMID 23797875, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG12147-PA
CKIa-like
NP_649536.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5425369..5427257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141279.2 → NP_649536.1  uncharacterized protein Dmel_CG12147 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649536.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JWT4
    Related
    FBpp0078437, FBtr0078793
    Conserved Domains (2) summary
    COG0515
    Location:67 → 306
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd14016
    Location:67 → 331
    STKc_CK1; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JWT4 Q7JWT4

Gene LinkOut

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