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gnb3b guanine nucleotide binding protein (G protein), beta polypeptide 3b [ Danio rerio (zebrafish) ]

Gene ID: 406483, updated on 4-Jan-2025

Summary

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Official Symbol
gnb3bprovided by ZNC
Official Full Name
guanine nucleotide binding protein (G protein), beta polypeptide 3bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2280
See related
Ensembl:ENSDARG00000002696 AllianceGenome:ZFIN:ZDB-GENE-040426-2280
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
gnb3; zgc:73058; zgc:77780; wu:fk54b04
Summary
Predicted to enable signaling receptor complex adaptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in epiphysis; eye; pineal complex; retina; and retinal cone cell. Human ortholog(s) of this gene implicated in artery disease (multiple); congenital stationary night blindness 1H; depressive disorder; familial hyperlipidemia; and type 2 diabetes mellitus. Orthologous to human GNB3 (G protein subunit beta 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See gnb3b in Genome Data Viewer
Location:
chromosome: 19
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (5106226..5125527, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (5189740..5209178, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene enolase 2 Neighboring gene uncharacterized LOC137488464 Neighboring gene triosephosphate isomerase 1a Neighboring gene si:dkey-89b17.4 Neighboring gene syntaxin 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transducin duplicates in the zebrafish retina and pineal complex: differential specialisation after the teleost tetraploidisation. Lagman D, et al. PLoS One, 2015. PMID 25806532, Free PMC Article
  2. Knockout of SWS2 in zebrafish (Danio rerio) reveals its roles in feeding and phototactic behaviors. Wang YY, et al. Gene, 2024 Mar 1. PMID 38043833
  3. Retinal degeneration in rpgra mutant zebrafish. Liu X, et al. Front Cell Dev Biol, 2023. PMID 37351277, Free PMC Article
  4. Ablation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophy. Lu Z, et al. Sci Rep, 2017 Apr 5. PMID 28378834, Free PMC Article
  5. Post-GWAS screening of candidate genes for refractive error in mutant zebrafish models. Quint WH, et al. Sci Rep, 2023 Feb 3. PMID 36737489, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables signaling receptor complex adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3b
Names
guanine nucleotide binding protein (G protein), beta polypeptide 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213202.1 → NP_998367.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3b

    See identical proteins and their annotated locations for NP_998367.1

    Status: PROVISIONAL

    Source sequence(s)
    BC065866
    UniProtKB/TrEMBL
    Q6P025, Q6PC87
    Related
    ENSDARP00000005843.6, ENSDART00000005547.8
    Conserved Domains (3) summary
    COG2319
    Location:46 → 338
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:48 → 338
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:58 → 95
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    5106226..5125527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159345.5 → XP_005159402.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3b isoform X1

    See identical proteins and their annotated locations for XP_005159402.1

    UniProtKB/TrEMBL
    Q6P025, Q6PC87
    Related
    ENSDARP00000120734.2, ENSDART00000132642.4
    Conserved Domains (3) summary
    COG2319
    Location:46 → 338
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:48 → 338
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:58 → 95
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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