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amfra autocrine motility factor receptor a [ Danio rerio (zebrafish) ]

Gene ID: 406442, updated on 9-Dec-2024

Summary

Official Symbol
amfraprovided by ZNC
Official Full Name
autocrine motility factor receptor aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2190
See related
Ensembl:ENSDARG00000020218 AllianceGenome:ZFIN:ZDB-GENE-040426-2190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
amfr; gp78; zgc:63893; wu:fi06e06; wu:fi37e05
Summary
Enables ubiquitin protein ligase activity. Acts upstream of or within protein polyubiquitination and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane. Is expressed in brain; digestive system; eye; heart; and muscle. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 89. Orthologous to human AMFR (autocrine motility factor receptor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See amfra in Genome Data Viewer
Location:
chromosome: 25
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (36197733..36218023, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (35648014..35668320, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene RPGRIP1 like Neighboring gene retinoblastoma-like 2 (p130) Neighboring gene uncharacterized LOC137489387 Neighboring gene iroquois homeobox 5b Neighboring gene nuclear factor of activated T cells 3b Neighboring gene dihydrouridine synthase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase AMFR
Names
AMF receptor
autocrine motility factor receptor, E3 ubiquitin protein ligase a
NP_998328.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213163.2NP_998328.2  E3 ubiquitin-protein ligase AMFR

    Status: VALIDATED

    Source sequence(s)
    CU855766
    UniProtKB/Swiss-Prot
    A0A8M3AWU0, F1QB30, Q6PFU8
    Related
    ENSDARP00000106624.2, ENSDART00000122559.4
    Conserved Domains (3) summary
    cd14421
    Location:451491
    CUE_AMFR; CUE domain found in autocrine motility factor receptor (AMFR) and similar proteins
    cd16455
    Location:332375
    RING-H2_AMFR; RING finger, H2 subclass, found in autocrine motility factor receptor (AMFR) and similar proteins
    cl26329
    Location:79375
    zf-rbx1; RING-H2 zinc finger domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    36197733..36218023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)