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7B2 7B2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40644, updated on 9-Dec-2024

Summary

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Official Symbol
7B2provided by FlyBase
Official Full Name
7B2provided by FlyBase
Primary source
FLYBASE:FBgn0041707
Locus tag
Dmel_CG1168
See related
AllianceGenome:FB:FBgn0041707
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1168; d7B2; Dmel\CG1168; FBgn0040073
Summary
Enables peptidase activator activity. Involved in positive regulation of proteolysis. Predicted to be located in secretory granule. Is expressed in adult head; embryonic brain; and larval ventral nerve cord. Orthologous to human SCG5 (secretogranin V). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See 7B2 in Genome Data Viewer
Location:
83A1-83A1; 3-47.5 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5376780..5377975)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1202502..1203697)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene humpty dumpty Neighboring gene uncharacterized protein Neighboring gene krotzkopf verkehrt Neighboring gene transfer RNA:Arginine-TCG 4-1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2. Insect cell-specific processing and secretion. Hwang JR, et al. J Biol Chem, 2000 Jun 9. PMID 10749852
  2. Insect chitin synthase cDNA sequence, gene organization and expression. Tellam RL, et al. Eur J Biochem, 2000 Oct. PMID 10998064
  3. The Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpin. Richer MJ, et al. Proc Natl Acad Sci U S A, 2004 Jul 20. PMID 15247425, Free PMC Article
  4. Heterogeneity in the Response of Different Subtypes of Drosophila melanogaster Midgut Cells to Viral Infections. Silva JMF, et al. Viruses, 2021 Nov 15. PMID 34835089, Free PMC Article
  5. Analysis of the transcriptomes downstream of Eyeless and the Hedgehog, Decapentaplegic and Notch signaling pathways in Drosophila melanogaster. Nfonsam LE, et al. PLoS One, 2012. PMID 22952997, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of hormone secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in secretory granule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
7B2
Names
7B2-PA
7B2-PB
CG1168-PA
CG1168-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5376780..5377975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014608.2 → NP_001014608.1  7B2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014608.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E4NKI5, Q59E04, Q9N9Z7, Q9VNB0
    Conserved Domains (1) summary
    pfam05281
    Location:45 → 275
    Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)

  2. NM_138986.4 → NP_620471.3  7B2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_620471.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNB0
    Related
    FBpp0078435
    Conserved Domains (1) summary
    pfam05281
    Location:40 → 270
    Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q59E04.1 Q59E04

Gene LinkOut

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