pdhb pyruvate dehydrogenase E1 subunit beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pdhbprovided by ZNC
Official Full Name: pyruvate dehydrogenase E1 subunit betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2173
See related: Ensembl:ENSDARG00000021346 AllianceGenome:ZFIN:ZDB-GENE-040426-2173
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:64062; wu:fc76a05
Summary: Enables pyruvate dehydrogenase activity. Acts upstream of or within pigmentation. Predicted to be part of pyruvate dehydrogenase complex. Is expressed in alar plate midbrain region; musculature system; optic tectum; optic vesicle; and pronephric duct. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHB (pyruvate dehydrogenase E1 subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (10201865..10212502)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (10172183..10182820)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables pyruvate dehydrogenase (acetyl-transferring) activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyruvate dehydrogenase (acetyl-transferring) activity	IEA Inferred from Electronic Annotation more info
enables pyruvate dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within acetyl-CoA biosynthetic process from pyruvate	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of pyruvate dehydrogenase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Names: DKEYP-87E7.2; nir; noir; pyruvate dehydrogenase (lipoamide) beta; pyruvate dehydrogenase E1 beta subunit

NP_998319.1

EC 1.2.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213154.1 → NP_998319.1 pyruvate dehydrogenase E1 component subunit beta, mitochondrial

See identical proteins and their annotated locations for NP_998319.1

Status: PROVISIONAL

Source sequence(s)

BC053233

UniProtKB/TrEMBL

A0A8M1PEP2, Q7T368

Related

ENSDARP00000002122.7, ENSDART00000006513.9

Conserved Domains (3) summary

cd07036
Location:37 → 203

TPP_PYR_E1-PDHc-beta_like; Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins

PLN02683
Location:8 → 356

PLN02683; pyruvate dehydrogenase E1 component subunit beta

pfam02780
Location:226 → 349

Transketolase_C; Transketolase, C-terminal domain