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ddost dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) [ Danio rerio (zebrafish) ]

Gene ID: 406408, updated on 4-Jan-2025

Summary

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Official Symbol
ddostprovided by ZNC
Official Full Name
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2147
See related
Ensembl:ENSDARG00000037318 AllianceGenome:ZFIN:ZDB-GENE-040426-2147
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:66068; zgc:77478; wu:fa11d01
Summary
Predicted to be involved in protein N-linked glycosylation via asparagine. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of oligosaccharyltransferase complex. Is expressed in axis; notochord; and polster. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ir. Orthologous to human DDOST (dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See ddost in Genome Data Viewer
Location:
chromosome: 23
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (24227296..24234287, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (24300745..24307736, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene anoctamin 11 Neighboring gene pleckstrin homology domain containing, family M (with RUN domain) member 2 Neighboring gene zinc finger and BTB domain containing 17 Neighboring gene heat shock protein family, member 7 (cardiovascular)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Impaired dopaminergic neuron development and locomotor function in zebrafish with loss of pink1 function. Xi Y, et al. Eur J Neurosci, 2010 Feb. PMID 20141529
  2. A central function for perlecan in skeletal muscle and cardiovascular development. Zoeller JJ, et al. J Cell Biol, 2008 Apr 21. PMID 18426981, Free PMC Article
  3. Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota. Rawls JF, et al. Proc Natl Acad Sci U S A, 2004 Mar 30. PMID 15070763, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein N-linked glycosylation via asparagine IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Names
DDOST 48 kDa subunit
dolichyl-diphosphooligosaccharide-protein glycosyltransferase
oligosaccharyl transferase 48 kDa subunit
NP_998258.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213093.1 → NP_998258.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor

    See identical proteins and their annotated locations for NP_998258.1

    Status: PROVISIONAL

    Source sequence(s)
    BC066475
    UniProtKB/Swiss-Prot
    Q6NYS8, Q6PHG6
    UniProtKB/TrEMBL
    A0A0R4I9F5
    Related
    ENSDARP00000105892.2, ENSDART00000124539.3
    Conserved Domains (1) summary
    pfam03345
    Location:33 → 440
    DDOST_48kD; Oligosaccharyltransferase 48 kDa subunit beta

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    24227296..24234287 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NYS8.2 GenPept UniProtKB/Swiss-Prot:Q6NYS8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.