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mdh2 malate dehydrogenase 2, NAD (mitochondrial) [ Danio rerio (zebrafish) ]

Gene ID: 406405, updated on 9-Dec-2024

Summary

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Official Symbol
mdh2provided by ZNC
Official Full Name
malate dehydrogenase 2, NAD (mitochondrial)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2143
See related
Ensembl:ENSDARG00000043371 AllianceGenome:ZFIN:ZDB-GENE-040426-2143
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:64133; wu:fj48c08; wu:fj55d06
Summary
Predicted to enable L-malate dehydrogenase (NAD+) activity. Predicted to be involved in tricarboxylic acid cycle. Predicted to act upstream of or within malate metabolic process. Predicted to be active in mitochondrion. Is expressed in alar plate midbrain region; brain; eye; immature eye; and musculature system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See mdh2 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (33218330..33392170)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (33439235..33448259)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496525 Neighboring gene myosin, light chain 10, regulatory Neighboring gene collagen, type XXVI, alpha 1 Neighboring gene BAF chromatin remodeling complex subunit BCL7B a Neighboring gene transducin beta like 2 Neighboring gene PR domain containing 15 Neighboring gene C2 calcium dependent domain containing 2 Neighboring gene microRNA 301a-1 Neighboring gene microRNA 130a-1 Neighboring gene testis expressed 14, intercellular bridge forming factor Neighboring gene microRNA 454a Neighboring gene zgc:153345 Neighboring gene spindle and kinetochore associated complex subunit 2 Neighboring gene uncharacterized LOC137496526 Neighboring gene ryanodine receptor 1a (skeletal)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Targeted toxicometabolomics of endosulfan sulfate in adult zebrafish (Danio rerio) using GC-MS/MS in multiple reaction monitoring mode. Lee HK, et al. J Hazard Mater, 2020 May 5. PMID 32000124
  2. Proteome profile of zebrafish Danio rerio olfactory bulb based on two-dimensional gel electrophoresis matrix-assisted laser desorption/ionization MS/MS analysis. Singh SK, et al. Zebrafish, 2011 Dec. PMID 22181661
  3. Characterization of Biological Pathways Regulating Acute Cold Resistance of Zebrafish. Ren J, et al. Int J Mol Sci, 2021 Mar 16. PMID 33809683, Free PMC Article
  4. In vivo identification of potential uranium protein targets in zebrafish ovaries after chronic waterborne exposure. Eb-Levadoux Y, et al. Metallomics, 2017 May 24. PMID 28317950
  5. Proteomic analysis of the Rett syndrome experimental model mecp2(Q63X) mutant zebrafish. Cortelazzo A, et al. J Proteomics, 2017 Feb 10. PMID 28062374

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-malate dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-malate dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables malate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within malate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
malate dehydrogenase, mitochondrial
NP_998296.1
XP_068079862.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213131.1 → NP_998296.1  malate dehydrogenase, mitochondrial

    See identical proteins and their annotated locations for NP_998296.1

    Status: PROVISIONAL

    Source sequence(s)
    BC053272
    UniProtKB/TrEMBL
    A0A8M1PNU6, Q7T334
    Related
    ENSDARP00000063661.4, ENSDART00000063662.6
    Conserved Domains (2) summary
    cd01337
    Location:25 → 333
    MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases
    PLN00106
    Location:6 → 328
    PLN00106; malate dehydrogenase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    33218330..33392170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068223761.1 → XP_068079862.1  malate dehydrogenase, mitochondrial isoform X1

Nucleotide Protein
Heading Accession and Version

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