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grb2b growth factor receptor-bound protein 2b [ Danio rerio (zebrafish) ]

Gene ID: 406308, updated on 9-Dec-2024

Summary

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Official Symbol
grb2bprovided by ZNC
Official Full Name
growth factor receptor-bound protein 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1975
See related
Ensembl:ENSDARG00000038059 AllianceGenome:ZFIN:ZDB-GENE-040426-1975
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
grb2; fb18e12; zgc:73077; wu:fb18e12; wu:fb34e06
Summary
Predicted to enable epidermal growth factor receptor binding activity and phosphotyrosine residue binding activity. Acts upstream of or within lymphangiogenesis. Predicted to be located in Golgi apparatus and endosome. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm; nucleoplasm; and plasma membrane. Is expressed in central nervous system and trigeminal placode. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See grb2b in Genome Data Viewer
Location:
chromosome: 3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (25436484..25492345, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (25306051..25361832, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene bromodomain PHD finger transcription factor Neighboring gene transfer RNA serine (anticodon AGA) Neighboring gene melanin-concentrating hormone receptor 1b Neighboring gene ubiquitin specific peptidase 43b Neighboring gene uncharacterized LOC101886214

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cautious use of fli1a:EGFP transgenic zebrafish in vascular research. Liu Z, et al. Biochem Biophys Res Commun, 2012 Oct 12. PMID 22995292
  2. The adaptor protein Grb2b is an essential modulator for lympho-venous sprout formation in the zebrafish trunk. Mauri C, et al. Angiogenesis, 2021 May. PMID 33677657, Free PMC Article
  3. Whole-genome expression profile in zebrafish embryos after chronic exposure to morphine: identification of new genes associated with neuronal function and mu opioid receptor expression. Herrero-Turrión MJ, et al. BMC Genomics, 2014 Oct 8. PMID 25294025, Free PMC Article
  4. CRK and NCK adaptors may functionally overlap in zebrafish neurodevelopment, as indicated by common binding partners and overlapping expression patterns. Stergas HR, et al. FEBS Lett, 2024 Feb. PMID 38058169
  5. Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration. Wu Z, et al. Protein Cell, 2023 May 8. PMID 37155312, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The adaptor protein Grb2b is an essential modulator for lympho-venous sprout formation in the zebrafish trunk.
    Title: The adaptor protein Grb2b is an essential modulator for lympho-venous sprout formation in the zebrafish trunk.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables epidermal growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphotyrosine residue binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lymphangiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
growth factor receptor-bound protein 2b
Names
growth factor receptor-bound protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213035.1 → NP_998200.1  growth factor receptor-bound protein 2b

    See identical proteins and their annotated locations for NP_998200.1

    Status: PROVISIONAL

    Source sequence(s)
    BC059450
    UniProtKB/TrEMBL
    A0A8M1PEH0, Q6PC73
    Related
    ENSDARP00000146459.1, ENSDART00000184651.1
    Conserved Domains (3) summary
    cd09941
    Location:56 → 150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:1 → 56
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:160 → 212
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    25436484..25492345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171575.5 → XP_005171632.1  growth factor receptor-bound protein 2b isoform X1

    See identical proteins and their annotated locations for XP_005171632.1

    UniProtKB/TrEMBL
    A0A8M1PEH0, Q6PC73
    Related
    ENSDARP00000055472.3, ENSDART00000055473.6
    Conserved Domains (3) summary
    cd09941
    Location:56 → 150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:1 → 56
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:160 → 212
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

  2. XM_009299360.4 → XP_009297635.1  growth factor receptor-bound protein 2b isoform X1

    See identical proteins and their annotated locations for XP_009297635.1

    UniProtKB/TrEMBL
    A0A8M1PEH0, Q6PC73
    Conserved Domains (3) summary
    cd09941
    Location:56 → 150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:1 → 56
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:160 → 212
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

  3. XM_005171574.5 → XP_005171631.1  growth factor receptor-bound protein 2b isoform X1

    See identical proteins and their annotated locations for XP_005171631.1

    UniProtKB/TrEMBL
    A0A8M1PEH0, Q6PC73
    Related
    ENSDARP00000122829.1, ENSDART00000147322.3
    Conserved Domains (3) summary
    cd09941
    Location:56 → 150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:1 → 56
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:160 → 212
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

  4. XM_017353773.3 → XP_017209262.1  growth factor receptor-bound protein 2b isoform X1

    UniProtKB/TrEMBL
    A0A8M1PEH0, Q6PC73
    Conserved Domains (3) summary
    cd09941
    Location:56 → 150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:1 → 56
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:160 → 212
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

  5. XM_017353775.3 → XP_017209264.1  growth factor receptor-bound protein 2b isoform X1

    UniProtKB/TrEMBL
    A0A8M1PEH0, Q6PC73
    Conserved Domains (3) summary
    cd09941
    Location:56 → 150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:1 → 56
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:160 → 212
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
Nucleotide Protein Strain
Heading Accession and Version

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