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cluap1 clusterin associated protein 1 [ Danio rerio (zebrafish) ]

Gene ID: 406281, updated on 4-Jan-2025

Summary

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Official Symbol
cluap1provided by ZNC
Official Full Name
clusterin associated protein 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1943
See related
Ensembl:ENSDARG00000079110 AllianceGenome:ZFIN:ZDB-GENE-040426-1943
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj16b11; unm_au5; zgc:56115; wu:fj16b11
Summary
Acts upstream of or within cilium assembly; kidney development; and photoreceptor cell maintenance. Predicted to be located in cell projection and nucleus. Predicted to be part of intraciliary transport particle B. Predicted to be active in cilium and microtubule organizing center. Orthologous to human CLUAP1 (clusterin associated protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See cluap1 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (37466770..37484128, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (37579050..37596410, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene SH3 domain binding kinase 1 Neighboring gene si:ch211-183d21.1 Neighboring gene NLR family, CARD domain containing 3 Neighboring gene WD repeat domain 90 Neighboring gene ras homolog family member T2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. High-throughput methodology to identify CRISPR-generated Danio rerio mutants using fragment analysis with unmodified PCR products. Colijn S, et al. Dev Biol, 2022 Apr. PMID 35149003, Free PMC Article
  2. Hypomorphic mutations identified in the candidate Leber congenital amaurosis gene CLUAP1. Soens ZT, et al. Genet Med, 2016 Oct. PMID 26820066, Free PMC Article
  3. Cluap1 is essential for ciliogenesis and photoreceptor maintenance in the vertebrate eye. Lee C, et al. Invest Ophthalmol Vis Sci, 2014 Jun 26. PMID 24970261, Free PMC Article
  4. Qilin is essential for cilia assembly and normal kidney development in zebrafish. Li J, et al. PLoS One, 2011. PMID 22102889, Free PMC Article
  5. An ENU mutagenesis screen in zebrafish for visual system mutants identifies a novel splice-acceptor site mutation in patched2 that results in Colobomas. Lee J, et al. Invest Ophthalmol Vis Sci, 2012 Dec 13. PMID 23150614, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within kidney development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within photoreceptor cell maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
part_of intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
clusterin-associated protein 1 homolog
Names
qil
qilin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213008.1 → NP_998173.1  clusterin-associated protein 1 homolog

    See identical proteins and their annotated locations for NP_998173.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045921
    UniProtKB/Swiss-Prot
    Q4V941, Q6NWG3, Q7ZVC2
    Related
    ENSDARP00000101015.2, ENSDART00000111623.4
    Conserved Domains (2) summary
    pfam10234
    Location:19 → 278
    Cluap1; Clusterin-associated protein-1
    cl12013
    Location:161 → 278
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    37466770..37484128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068217047.1 → XP_068073148.1  clusterin-associated protein 1 homolog isoform X4

    UniProtKB/Swiss-Prot
    Q4V941, Q6NWG3, Q7ZVC2

  2. XM_021470122.2 → XP_021325797.1  clusterin-associated protein 1 homolog isoform X3

    UniProtKB/Swiss-Prot
    Q4V941, Q6NWG3, Q7ZVC2
    UniProtKB/TrEMBL
    A0A8M9P5T3
    Conserved Domains (1) summary
    pfam10234
    Location:19 → 279
    Cluap1; Clusterin-associated protein-1

  3. XM_021470121.2 → XP_021325796.1  clusterin-associated protein 1 homolog isoform X2

    UniProtKB/Swiss-Prot
    Q4V941, Q6NWG3, Q7ZVC2
    UniProtKB/TrEMBL
    A0A8M9PTX5
    Conserved Domains (1) summary
    pfam10234
    Location:19 → 279
    Cluap1; Clusterin-associated protein-1

  4. XM_021470120.2 → XP_021325795.1  clusterin-associated protein 1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q4V941, Q6NWG3, Q7ZVC2
    UniProtKB/TrEMBL
    A0A8M9PXC0
    Conserved Domains (1) summary
    pfam10234
    Location:19 → 279
    Cluap1; Clusterin-associated protein-1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZVC2.2 GenPept UniProtKB/Swiss-Prot:Q7ZVC2

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