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RabGGTa Rab geranylgeranyltransferase subunit alpha [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40617, updated on 4-Jan-2025

Summary

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Official Symbol
RabGGTaprovided by FlyBase
Official Full Name
Rab geranylgeranyltransferase subunit alphaprovided by FlyBase
Primary source
FLYBASE:FBgn0037293
Locus tag
Dmel_CG12007
See related
AllianceGenome:FB:FBgn0037293
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12007; Dmel\CG12007; PTAR3; RabGGTalpha
Summary
Contributes to Rab geranylgeranyltransferase activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Part of Rab-protein geranylgeranyltransferase complex. Is expressed in organism. Orthologous to human RABGGTA (Rab geranylgeranyltransferase subunit alpha). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See RabGGTa in Genome Data Viewer
Location:
82F1-82F1; 3-47.5 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5128087..5129939)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (953809..955661)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene corto Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene defective proboscis extension response 16 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of Drosophila eye development by the transcription factor Sine oculis. Jusiak B, et al. PLoS One, 2014. PMID 24586968, Free PMC Article
  2. Isoprenoids control germ cell migration downstream of HMGCoA reductase. Santos AC, et al. Dev Cell, 2004 Feb. PMID 14960281
  3. Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11. Charng WL, et al. PLoS Biol, 2014 Jan. PMID 24492843, Free PMC Article
  4. Genome-wide mapping of in vivo targets of the Drosophila transcription factor Kruppel. Matyash A, et al. J Biol Chem, 2004 Jul 16. PMID 15131112
  5. Identification and functional analysis of healing regulators in Drosophila. Álvarez-Fernández C, et al. PLoS Genet, 2015. PMID 25647511, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to Rab geranylgeranyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to Rab geranylgeranyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein prenyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein prenylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Rab-protein geranylgeranyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rab-protein geranylgeranyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rab geranylgeranyltransferase subunit alpha
Names
CG12007-PA
RabGGTa-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5128087..5129939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141255.3 → NP_649512.1  Rab geranylgeranyltransferase subunit alpha [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649512.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VN77
    Related
    FBpp0078483
    Conserved Domains (2) summary
    COG5536
    Location:21 → 267
    BET4; Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones]
    pfam01239
    Location:124 → 151
    PPTA; Protein prenyltransferase alpha subunit repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VN77 Q9VN77

Gene LinkOut

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