ntmt1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ntmt1provided by ZNC
Official Full Name: N-terminal Xaa-Pro-Lys N-methyltransferase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2055
See related: Ensembl:ENSDARG00000022399 AllianceGenome:ZFIN:ZDB-GENE-040426-2055
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: NTM1A; mettl11a; zgc:77488
Summary: Predicted to enable N-terminal protein N-methyltransferase activity and histone methyltransferase activity. Predicted to be involved in N-terminal protein amino acid methylation; chromosome segregation; and spindle organization. Predicted to act upstream of or within N-terminal protein amino acid methylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including lens placode; muscle; optic vesicle; paraxial mesoderm; and presumptive neural retina. Orthologous to human NTMT1 (N-terminal Xaa-Pro-Lys N-methyltransferase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (32499069..32505347, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (31898916..31905219, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc07d08.x1 (e-PCR)
- UniSTS:192284

fc03h02.x1 (e-PCR)
- UniSTS:192138

fc03h02.x1 (e-PCR)
- UniSTS:192139

fc41f01.x1 (e-PCR)
- UniSTS:188146

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables N-terminal protein N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-terminal protein N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables N-terminal protein N-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-terminal peptidyl-glycine methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in N-terminal peptidyl-proline dimethylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in N-terminal peptidyl-serine dimethylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in N-terminal peptidyl-serine trimethylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within N-terminal protein amino acid methylation	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: N-terminal Xaa-Pro-Lys N-methyltransferase 1

Names: X-Pro-Lys N-terminal protein methyltransferase 1A; alpha N-terminal protein methyltransferase 1A; methyltransferase like 11A; methyltransferase-like protein 11A

NP_998063.1

EC 2.1.1.244

XP_005171881.1

EC 2.1.1.244

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212898.1 → NP_998063.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1

See identical proteins and their annotated locations for NP_998063.1

Status: PROVISIONAL

Source sequence(s)

BC067378

UniProtKB/Swiss-Prot

Q6NWX7

UniProtKB/TrEMBL

A0A2R8Q009, A0A8M2BJ61

Related

ENSDARP00000033698.6, ENSDART00000034705.7

Conserved Domains (1) summary

cl17173
Location:8 → 223

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

32499069..32505347 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005171824.5 → XP_005171881.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X1

See identical proteins and their annotated locations for XP_005171881.1

UniProtKB/TrEMBL

A0A2R8Q009, A0A8M2BJ61, A0A8M3ASF9, F1QAE8

Related

ENSDARP00000153947.1, ENSDART00000188219.1

Conserved Domains (1) summary

cl17173
Location:8 → 223

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...