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dpydb dihydropyrimidine dehydrogenase b [ Danio rerio (zebrafish) ]

Gene ID: 405829, updated on 9-Dec-2024

Summary

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Official Symbol
dpydbprovided by ZNC
Official Full Name
dihydropyrimidine dehydrogenase bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2459
See related
Ensembl:ENSDARG00000010267 AllianceGenome:ZFIN:ZDB-GENE-040426-2459
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dpyd; zgc:77205
Summary
Predicted to enable NADP binding activity; dihydropyrimidine dehydrogenase (NADP+) activity; and uracil binding activity. Predicted to be involved in thymidine catabolic process; thymine catabolic process; and uracil catabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in intestinal bulb; liver; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See dpydb in Genome Data Viewer
Location:
chromosome: 2
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (19825299..20120173, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (20167150..20462201, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene RWD domain containing 3 Neighboring gene polypyrimidine tract binding protein 2b Neighboring gene uncharacterized LOC137487806 Neighboring gene microRNA 137-1 Neighboring gene uncharacterized LOC137487803

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Metabolism disruption analysis of zebrafish larvae in response to BPA and BPA analogs based on RNA-Seq technique. Qiu W, et al. Ecotoxicol Environ Saf, 2019 Jun 15. PMID 30826544
  2. Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage-specific losses. Petit D, et al. Mol Biol Evol, 2015 Apr. PMID 25534026, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC77205

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydropyrimidine dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydropyrimidine dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydropyrimidine dehydrogenase (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables uracil binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in beta-alanine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in thymidine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in thymine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in uracil catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in uracil catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dihydropyrimidine dehydrogenase [NADP(+)]
Names
DHPDHase
DPD
dihydrothymine dehydrogenase
dihydrouracil dehydrogenase
NP_998058.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212893.1 → NP_998058.1  dihydropyrimidine dehydrogenase [NADP(+)]

    See identical proteins and their annotated locations for NP_998058.1

    Status: PROVISIONAL

    Source sequence(s)
    BC066602
    UniProtKB/Swiss-Prot
    Q6NYG8
    Related
    ENSDARP00000108791.2, ENSDART00000124724.4
    Conserved Domains (6) summary
    PRK08318
    Location:532 → 1020
    PRK08318; dihydropyrimidine dehydrogenase subunit B; Validated
    PRK11749
    Location:58 → 509
    PRK11749; dihydropyrimidine dehydrogenase subunit A; Provisional
    cd02940
    Location:532 → 834
    DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
    pfam13187
    Location:952 → 996
    Fer4_9; 4Fe-4S dicluster domain
    pfam13450
    Location:193 → 238
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    pfam14691
    Location:56 → 168
    Fer4_20; Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    19825299..20120173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NYG8.1 GenPept UniProtKB/Swiss-Prot:Q6NYG8

Gene LinkOut

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