lactb2 lactamase, beta 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lactb2provided by ZNC
Official Full Name: lactamase, beta 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2257
See related: AllianceGenome:ZFIN:ZDB-GENE-040426-2257
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77065
Summary: Predicted to enable RNA endonuclease activity; single-stranded RNA binding activity; and zinc ion binding activity. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to human LACTB2 (lactamase beta 2). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: Un

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	Unplaced Scaffold	NW_003336554.1 (6515..7267)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_003336554.1 (6515..7267)

NW_003336554.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA endonuclease activity, producing 3'-phosphomonoesters	IEA Inferred from Electronic Annotation more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: endoribonuclease LACTB2

Names: beta-lactamase-like protein 2

NP_998049.1

EC 3.1.27.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212884.1 → NP_998049.1 endoribonuclease LACTB2

See identical proteins and their annotated locations for NP_998049.1

Status: PROVISIONAL

Source sequence(s)

BC066620

UniProtKB/Swiss-Prot

Q6NYF0

Conserved Domains (2) summary

COG0491
Location:23 → 217

GloB; Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only]

cd07722
Location:14 → 203

LACTB2-like_MBL-fold; uncharacterized subgroup which includes human lactamase beta 2 and related proteins; MBL-fold metallo hydrolase domain