kcnh6a potassium voltage-gated channel, subfamily H (eag-related), member 6a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kcnh6aprovided by ZNC
Official Full Name: potassium voltage-gated channel, subfamily H (eag-related), member 6aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040702-5
See related: Ensembl:ENSDARG00000001803 AllianceGenome:ZFIN:ZDB-GENE-040702-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: erg; kcnh2; kcnh6
Summary: Enables voltage-gated potassium channel activity. Acts upstream of or within several processes, including heart contraction; membrane repolarization during cardiac muscle cell action potential; and regulation of ventricular cardiac muscle cell membrane repolarization. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; digestive system; gill; immune system; and muscle. Used to study long QT syndrome; long QT syndrome 2; and short QT syndrome. Orthologous to human KCNH6 (potassium voltage-gated channel subfamily H member 6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (31728868..31784073, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (31597154..31652454, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNF207 is an important regulator of action potential duration, likely via effects on HERG trafficking and localization in a heat shock protein-dependent manner.
Title: RING finger protein RNF207, a novel regulator of cardiac excitation.
The data support the conclusion that zerg-2 and zerg-3 are apparent orthologues of different human genes encoding potassium ion channels, but that their functions have switched compared to the respective human proteins.
Title: Identification and expression analysis of kcnh2 genes in the zebrafish.
The reg mutation in the voltage sensor of the ether-a-go-go-related gene gene K+ channel causes premature zERG channel activation & defective inactivation, resulting in shortened action-potential duration & accelerated cardiac repolarization
Title: Deficient zebrafish ether-à-go-go-related gene channel gating causes short-QT syndrome in zebrafish reggae mutants.
Mutations in kcnh2 recapitulate the human long QT syndrome (LQTS) phenotype as manifested by prolongation of action potentials and prolonged QT interval in the first animal genetic model of human LQTS type 2.
Title: Zebrafish model for human long QT syndrome.
role for ERG in leukocytes, where inhibition or translational knockdown of ERG resulted in significant attenuation of the inflammatory response to an infectious stimulus
Title: Class III antiarrhythmic methanesulfonanilides inhibit leukocyte recruitment in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables inward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane repolarization during cardiac muscle cell action potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within membrane repolarization during cardiac muscle cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart rate by cardiac conduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane repolarization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily H member 6a

Names: bre; breakdance; erg K+ channel; ether-a-go-go-related; potassium voltage-gated channel, subfamily H (eag-related), member 2; potassium voltage-gated channel, subfamily H (eag-related), member 6; reg; reggae; silent ventricle; unm s213; zerg; zerg-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212837.1 → NP_998002.1 potassium voltage-gated channel subfamily H member 6a

See identical proteins and their annotated locations for NP_998002.1

Status: PROVISIONAL

Source sequence(s)

AF532865

UniProtKB/TrEMBL

Q8JH78

Related

ENSDARP00000085242.6, ENSDART00000090809.6

Conserved Domains (4) summary

cd00038
Location:714 → 821

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd00130
Location:29 → 132

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam07885
Location:583 → 637

Ion_trans_2; Ion channel

pfam13426
Location:29 → 130

PAS_9; PAS domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

31728868..31784073 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005164007.5 → XP_005164064.1 potassium voltage-gated channel subfamily H member 6a isoform X1

UniProtKB/TrEMBL

A0A8M2BBD6

Conserved Domains (4) summary

cd00038
Location:714 → 821

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd00130
Location:29 → 132

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam07885
Location:583 → 637

Ion_trans_2; Ion channel

pfam13426
Location:29 → 130

PAS_9; PAS domain
XM_005164008.5 → XP_005164065.1 potassium voltage-gated channel subfamily H member 6a isoform X2

UniProtKB/TrEMBL

A0A8M2BBB6

Conserved Domains (4) summary

cd00038
Location:714 → 821

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd00130
Location:29 → 132

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam07885
Location:583 → 637

Ion_trans_2; Ion channel

pfam13426
Location:29 → 130

PAS_9; PAS domain