U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

aux auxilin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40527, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
auxprovided by FlyBase
Official Full Name
auxilinprovided by FlyBase
Primary source
FLYBASE:FBgn0037218
Locus tag
Dmel_CG1107
See related
AllianceGenome:FB:FBgn0037218
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.393; Aux; AUX; Auxilin; auxillin; Auxillin/DNAJC6; CG1107; dAux; Dmel\CG1107; DNAJC6; GAK
Summary
Predicted to enable AP-2 adaptor complex binding activity and protein serine/threonine kinase activity. Involved in clathrin-dependent endocytosis; compound eye morphogenesis; and sperm individualization. Located in Golgi stack. Is expressed in several structures, including adult head; embryonic/larval garland cell; embryonic/larval midgut primordium; garland cell primordium; and salivary gland body primordium. Used to study Parkinson's disease and Parkinson's disease 19A. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 19A. Orthologous to several human genes including GAK (cyclin G associated kinase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See aux in Genome Data Viewer
Location:
82A1-82A1; 3-47.1 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4211783..4227518)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (37505..53240)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Drosulfakinin Neighboring gene beta-Mannosidase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dihydropterin deaminase Neighboring gene uncharacterized protein Neighboring gene abstrakt

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Auxilin Underlies Progressive Locomotor Deficits and Dopaminergic Neuron Loss in a Drosophila Model of Parkinson's Disease. Song L, et al. Cell Rep, 2017 Jan 31. PMID 28147270
  2. Parkinsonism mutations in DNAJC6 cause lipid defects and neurodegeneration that are rescued by Synj1. Jacquemyn J, et al. NPJ Parkinsons Dis, 2023 Feb 4. PMID 36739293, Free PMC Article
  3. Cyclin-G-associated kinase GAK/dAux regulates autophagy initiation via ULK1/Atg1 in glia. Zhang S, et al. Proc Natl Acad Sci U S A, 2023 Jul 18. PMID 37428930, Free PMC Article
  4. Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS. Coyne AN, et al. Cell Rep, 2017 Oct 3. PMID 28978466, Free PMC Article
  5. Parkinson's disease risk genes act in glia to control neuronal α-synuclein toxicity. Olsen AL, et al. Neurobiol Dis, 2021 Nov. PMID 34390834, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila Rab11 and auxilin mutants to test the ligand recycling hypothesis.
    Title: The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling.
  2. Aux participates in forming these Golgi-derived clathrin-positive vesicles and therefore, has a role in the secretory pathway.
    Title: Auxilin is required for formation of Golgi-derived clathrin-coated vesicles during Drosophila spermatogenesis.
  3. ligand endocytosis is critical for Notch signaling and auxilin participates in Notch signaling by facilitating ligand internalization
    Title: The clathrin-binding motif and the J-domain of Drosophila Auxilin are essential for facilitating Notch ligand endocytosis.
  4. Auxilin, an endocytic factor that regulates Clathrin dynamics, is also essential for Notch signaling.
    Title: Auxilin is essential for Delta signaling.
  5. The data suggest that auxilin is an integral component of the Notch signaling pathway, participating in the ubiquitin-dependent endocytosis of Delta.
    Title: Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

mobile_element

  • Loc: 4215890-4215925 mobile_element_type = transposon:1360{}3728

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables AP-2 adaptor complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sperm individualization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi stack IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
auxilin
Names
CG1107-PA
CG1107-PB
CG1107-PC
CG1107-PD
aux-PA
aux-PB
aux-PC
aux-PD
auxillin
NP_001262243.1
NP_001262244.1
NP_649438.1
NP_730785.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    4211783..4227518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164317.3 → NP_730785.1  auxilin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730785.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VMY8
    Related
    FBpp0078604
    Conserved Domains (4) summary
    smart00271
    Location:1110 → 1150
    DnaJ; DnaJ molecular chaperone homology domain
    smart00220
    Location:51 → 317
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam10409
    Location:581 → 711
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl21453
    Location:49 → 326
    PKc_like; Protein Kinases, catalytic domain

  2. NM_141181.3 → NP_649438.1  auxilin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649438.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VMY8
    Related
    FBpp0078605
    Conserved Domains (4) summary
    smart00271
    Location:1110 → 1150
    DnaJ; DnaJ molecular chaperone homology domain
    smart00220
    Location:51 → 317
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam10409
    Location:581 → 711
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl21453
    Location:49 → 326
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001275314.1 → NP_001262243.1  auxilin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262243.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KG14
    Conserved Domains (4) summary
    smart00271
    Location:1098 → 1138
    DnaJ; DnaJ molecular chaperone homology domain
    smart00220
    Location:51 → 317
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam10409
    Location:581 → 711
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl21453
    Location:49 → 326
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001275315.1 → NP_001262244.1  auxilin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262244.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KF57
    Conserved Domains (5) summary
    smart00271
    Location:1102 → 1142
    DnaJ; DnaJ molecular chaperone homology domain
    smart00220
    Location:58 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam10409
    Location:573 → 703
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl10080
    Location:927 → 1009
    RPE65; Retinal pigment epithelial membrane protein
    cl21453
    Location:49 → 318
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KF57 A0A0B4KF57
A0A0B4KG14 A0A0B4KG14
Q8T0A7 Q8T0A7
Q9VMY8 Q9VMY8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools