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nAChRalpha4 nicotinic Acetylcholine Receptor alpha4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40521, updated on 4-Jan-2025

Summary

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Official Symbol
nAChRalpha4provided by FlyBase
Official Full Name
nicotinic Acetylcholine Receptor alpha4provided by FlyBase
Primary source
FLYBASE:FBgn0266347
Locus tag
Dmel_CG12414
See related
AllianceGenome:FB:FBgn0266347
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
alpha4; anon-WO0138359.1; CG12414; CG17552; Dalpha4; Dmel\CG12414; nAChR; nAChR-alpha80B; nAChRa4; nAcRalpha-4; nAcRalpha-80; nAcRalpha-80B; nAcRaplha-80B; redeye; rye
Summary
Contributes to acetylcholine receptor activity. Involved in sleep. Part of acetylcholine-gated channel complex. Is expressed in adult head; lamina monopolar neuron L4; and organism. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); gastrointestinal system cancer (multiple); and respiratory system cancer (multiple). Orthologous to several human genes including CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See nAChRalpha4 in Genome Data Viewer
Location:
80D5-80E3; 3-47 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (23206669..23287448)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (23199769..23280548)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43967 Neighboring gene long non-coding RNA:CR45735 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46475 Neighboring gene alpha Catenin Neighboring gene mir-4942 stem loop Neighboring gene NADH dehydrogenase (ubiquinone) MLRQ subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The endogenous antioxidant ability of royal jelly in Drosophila is independent of Keap1/Nrf2 by activating oxidoreductase activity. Wen D, et al. Insect Sci, 2024 Apr. PMID 37632209
  2. Availability of food determines the need for sleep in memory consolidation. Chouhan NS, et al. Nature, 2021 Jan. PMID 33268891, Free PMC Article
  3. Cloning and heterologous expression of Dalpha4, a Drosophila neuronal nicotinic acetylcholine receptor subunit: identification of an alternative exon influencing the efficiency of subunit assembly. Lansdell SJ, et al. Neuropharmacology, 2000 Oct. PMID 11044730
  4. Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount. Shi M, et al. Elife, 2014. PMID 24497543, Free PMC Article
  5. A Drosophila model of sleep restriction therapy for insomnia. Belfer SJ, et al. Mol Psychiatry, 2021 Feb. PMID 30824866, Free PMC Article

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Propose that the homeostatic drive to sleep increases levels of RYE, which responds to this drive by promoting sleep.
    Title: Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 23214034-23214082 mobile_element_type = transposon:INE-1{}3754
  • Loc: 23218788-23219072 mobile_element_type = transposon:INE-1{}3758
  • Loc: 23219681-23219797 mobile_element_type = transposon:297{}3807
  • Loc: 23219852-23224264 mobile_element_type = transposon:X{}1606
  • Loc: 23228423-23228527 mobile_element_type = transposon:INE-1{}3769
  • Loc: 23241916-23243038 mobile_element_type = transposon:1360{}1171
  • Loc: 23248105-23248334 mobile_element_type = transposon:INE-1{}4510
  • Loc: 23252656-23252973 mobile_element_type = transposon:INE-1{}4512
  • Loc: 23256350-23256483 mobile_element_type = transposon:G5{}5176
  • Loc: 23267007-23267531 mobile_element_type = transposon:Cr1a{}1170
  • Loc: 23271761-23276816 mobile_element_type = transposon:invader2{}1169
  • Loc: 23277858-23277953 mobile_element_type = transposon:INE-1{}4524
  • Loc: 23279422-23279467 mobile_element_type = transposon:Cr1a{}5145
  • Loc: 23279468-23283577 mobile_element_type = transposon:Cr1a{}1607
  • Loc: 23279613-23279961 mobile_element_type = transposon:gypsy8{}5279
  • Loc: 23282059-23283258 mobile_element_type = transposon:looper1{}5747
  • Loc: 23286500-23286608 mobile_element_type = transposon:INE-1{}4535

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to acetylcholine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetylcholine-gated monoatomic cation-selective channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity IEA
Inferred from Electronic Annotation
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sleep IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of acetylcholine-gated channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nicotinic acetylcholine receptor alpha4
Names
CG12414-PC
CG12414-PD
CG12414-PE
CG12414-PF
CG12414-PG
CG12414-PH
Dalpha4
nAChRalpha4-PC
nAChRalpha4-PD
nAChRalpha4-PE
nAChRalpha4-PF
nAChRalpha4-PG
nAChRalpha4-PH
nicotinic acetylcholine receptor alpha 4
nicotinic acetylcholine receptor alpha 80B
red-eye
redeye
NP_001097669.2
  • unusual splice
NP_001246895.1
  • unusual splice
NP_001246896.1
  • unusual splice
NP_001303394.1
  • unusual splice
NP_536742.3
  • unusual splice

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    23206669..23287448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104199.5 → NP_001097669.2  nicotinic acetylcholine receptor alpha4, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097669.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNX5, Q9NFR5
    Conserved Domains (3) summary
    TIGR00860
    Location:1 → 505
    LIC; Cation transporter family protein
    pfam02931
    Location:12 → 227
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:234 → 505
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  2. NM_001316465.1 → NP_001303394.1  nicotinic acetylcholine receptor alpha4, isoform H [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0S0WNY8, Q9NFR5
    Conserved Domains (3) summary
    TIGR00860
    Location:1 → 505
    LIC; Cation transporter family protein
    pfam02931
    Location:12 → 227
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:234 → 505
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  3. NM_001259966.3 → NP_001246895.1  nicotinic acetylcholine receptor alpha4, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246895.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NE13, Q058T0
    Conserved Domains (2) summary
    pfam02931
    Location:3 → 59
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:66 → 337
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  4. NM_001259967.2 → NP_001246896.1  nicotinic acetylcholine receptor alpha4, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246896.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NE13, Q058T0
    Conserved Domains (2) summary
    pfam02931
    Location:3 → 59
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:66 → 337
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  5. NM_001275305.1 → NP_001262234.1  nicotinic acetylcholine receptor alpha4, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262234.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDC9, Q9NFR5
    Conserved Domains (3) summary
    TIGR00860
    Location:1 → 465
    LIC; Cation transporter family protein
    pfam02931
    Location:12 → 227
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:234 → 465
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  6. NM_080494.3 → NP_536742.3  nicotinic acetylcholine receptor alpha4, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_536742.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q058T0, Q95RL8
    Conserved Domains (2) summary
    pfam02931
    Location:6 → 72
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:79 → 350
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0S0WNY8 A0A0S0WNY8
A8JNX5 A8JNX5
M9NE13 M9NE13
M9PDC9 M9PDC9
Q95RL8 Q95RL8
Q9NFR4 Q9NFR4
Q9NFR5 Q9NFR5

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