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CG11426 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40471, updated on 4-Jan-2025

Summary

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Official Symbol
CG11426provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037166
Locus tag
Dmel_CG11426
See related
AllianceGenome:FB:FBgn0037166
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Css1beta; Dmel\CG11426; LPP; LPP-like; PAP2; WUN-like
Summary
Predicted to enable phosphatidate phosphatase activity. Involved in phototransduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including CNS glial cell; embryonic head sensory system; embryonic optic lobe primordium; larval labral sensory complex; and sensory nervous system primordium. Orthologous to human PLPP1 (phospholipid phosphatase 1); PLPP2 (phospholipid phosphatase 2); and PLPP3 (phospholipid phosphatase 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG11426 in Genome Data Viewer
Location:
79E4-79E4; 3-47 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22470556..22473509)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22463656..22466609)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45382 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CG11426 gene product negatively regulates glial population size in the Drosophila eye imaginal disc. Rhee JE, et al. Dev Neurobiol, 2021 Sep. PMID 34047015
  2. Decoupled differentiation of gene expression and coding sequence among Drosophila populations. Kohn MH, et al. Genes Genet Syst, 2008 Jun. PMID 18670138
  3. lazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction. Garcia-Murillas I, et al. Neuron, 2006 Feb 16. PMID 16476663
  4. Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels. Raghu P, et al. J Cell Biol, 2009 Apr 6. PMID 19349583, Free PMC Article
  5. Identification of a family of animal sphingomyelin synthases. Huitema K, et al. EMBO J, 2004 Jan 14. PMID 14685263, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phototransduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG11426-PA
lipid phosphate phosphohydrolase
NP_649394.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    22470556..22473509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141137.3 → NP_649394.1  uncharacterized protein Dmel_CG11426 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649394.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5T219, Q7YU44, Q9VNT9
    Related
    FBpp0078158
    Conserved Domains (1) summary
    cd03384
    Location:130 → 285
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7YU44 Q7YU44
Q9VNT9 Q9VNT9

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