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Ten-m Tenascin major [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40464, updated on 4-Jan-2025

Summary

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Official Symbol
Ten-mprovided by FlyBase
Official Full Name
Tenascin majorprovided by FlyBase
Primary source
FLYBASE:FBgn0004449
Locus tag
Dmel_CG5723
See related
AllianceGenome:FB:FBgn0004449
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
2017; 5301; BcDNA:AT25108; CG11452; CG5723; CT16449; Dmel\CG5723; l(3)00844; l(3)05301; l(3)05309; l(3)rJ307; l(3)rL201; l(3)rP126; odd(Oz); odz; Odz; odz/ten-m; ten(m); ten-m; Ten-M; ten-m/odz; Ten-mc; Ten79E; ten[m]; Ten[m]
Summary
Enables filamin binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including neuron development; regulation of cell-cell adhesion; and synapse organization. Located in neuromuscular junction; neuronal cell body; and postsynaptic membrane. Is expressed in several structures, including adult sense organ; epithelium; imaginal disc; region of integument; and sensory system neurons. Human ortholog(s) of this gene implicated in cocaine dependence and essential tremor 5. Orthologous to several human genes including TENM1 (teneurin transmembrane protein 1); TENM2 (teneurin transmembrane protein 2); and TENM3 (teneurin transmembrane protein 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Ten-m in Genome Data Viewer
Location:
79D4-79E3; 3-47 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22293044..22407863, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22286144..22400963, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene HEM-protein Neighboring gene Isoleucyl-tRNA synthetase Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45963 Neighboring gene long non-coding RNA:CR45962 Neighboring gene long non-coding RNA:CR45964 Neighboring gene long non-coding RNA:CR45965 Neighboring gene long non-coding RNA:CR45237 Neighboring gene long non-coding RNA:CR45966

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Numerous recursive sites contribute to accuracy of splicing in long introns in flies. Pai AA, et al. PLoS Genet, 2018 Aug. PMID 30148878, Free PMC Article
  2. Ancient role of ten-m/odz in segmentation and the transition from sequential to syncytial segmentation. Hunding A, et al. Hereditas, 2017. PMID 28461810, Free PMC Article
  3. The Drosophila odz/ten-m gene encodes a type I, multiply cleaved heterodimeric transmembrane protein. Dgany O, et al. Biochem J, 2002 May 1. PMID 11964164, Free PMC Article
  4. The complexity in regulating the expression of tenascins. Chiquet-Ehrismann R, et al. Bioessays, 1995 Oct. PMID 7487968
  5. The Tenets of Teneurin: Conserved Mechanisms Regulate Diverse Developmental Processes in the Drosophila Nervous System. DePew AT, et al. Front Neurosci, 2019. PMID 30760977, Free PMC Article

See all (137) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ten-m/Odz may have had an ancient role in cell-cell communication, parallel to the Notch and wnt pathways. The Ten-m protein binds to the membrane with properties which resemble other membrane-based biochemical oscillators. The oscillatory properties of Ten-m may play a seminal role in arthropod segmentation.
    Title: Ancient role of ten-m/odz in segmentation and the transition from sequential to syncytial segmentation.
  2. Ten-m acts in projection neurons autonomously to regulate acetylcholine receptor cluster number and transsynaptically to regulate olfactory receptor neurons active zone number.
    Title: Synaptic organization of the Drosophila antennal lobe and its regulation by the Teneurins.
  3. identification of two evolutionarily conserved, epidermal growth factor (EGF)-repeat containing transmembrane Teneurin proteins, Ten-m and Ten-a, as synaptic-partner-matching molecules between projection neuron dendrites and olfactory receptor neuron axons
    Title: Teneurins instruct synaptic partner matching in an olfactory map.
  4. study identifies the Teneurins as a key bi-directional trans-synaptic signal involved in general synapse organization, and demonstrates that proteins such as these can also regulate target selection
    Title: Trans-synaptic Teneurin signalling in neuromuscular synapse organization and target choice.
  5. Data indicate that during embryonic development, the expression of Filamin and Ten-m partially overlap in ectodermal cells.
    Title: Drosophila Ten-m and filamin affect motor neuron growth cone guidance.
  6. the odz gene is required for multiple cell types in the compound retina
    Title: Drosophila odz gene is required for multiple cell types in the compound retina.
  7. The structure and membrane orientation of this large enigmatic protein was characterized by raising and employing antibodies directed against discrete Odz polypeptide regions.
    Title: The Drosophila odz/ten-m gene encodes a type I, multiply cleaved heterodimeric transmembrane protein.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables filamin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in R7 cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chaeta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye corneal lens development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye photoreceptor development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasmic microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of alignment of postsynaptic density and presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in maintenance of alignment of postsynaptic density and presynaptic active zone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of presynaptic active zone structure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in motor neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynaptic membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynaptic spectrin-associated cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynaptic spectrin-associated cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in presynaptic membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of homotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of homotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of terminal button organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic target attraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic target recognition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic target recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tenascin major
Names
CG5723-PB
CG5723-PD
CG5723-PE
Ten-m-PB
Ten-m-PD
Ten-m-PE
Teneurin-m
odd Oz
odd-Oz
tenascin-like molecule major
tenascin-major
teneurin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    22293044..22407863 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079491.3 → NP_524215.2  tenascin major, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524215.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8JNW8, O18366, O61307, Q24551, Q9TX59, Q9VNU6
    Related
    FBpp0078161
    Conserved Domains (12) summary
    COG3209
    Location:1781 → 2454
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1218 → 1264
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:2229 → 2270
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:2339 → 2414
    Rhs_assc_core; RHS repeat-associated core domain
    cd00185
    Location:549 → 594
    TNFRSF; CRD2 [structural motif]
    pfam01500
    Location:605 → 773
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:1617 → 1652
    RHS_repeat; RHS Repeat
    pfam07974
    Location:610 → 637
    EGF_2; EGF-like domain
    pfam12955
    Location:614 → 678
    DUF3844; Domain of unknown function (DUF3844)
    pfam15636
    Location:2627 → 2702
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1184 → 1499
    NHL; NHL repeat unit of beta-propeller proteins
    cl22855
    Location:512 → 611
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  2. NM_001275282.1 → NP_001262211.1  tenascin major, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262211.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGF7
    Conserved Domains (12) summary
    COG3209
    Location:2347 → 3020
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1784 → 1830
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:2795 → 2836
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:2905 → 2980
    Rhs_assc_core; RHS repeat-associated core domain
    cd00185
    Location:1106 → 1151
    TNFRSF; CRD2 [structural motif]
    pfam01500
    Location:1162 → 1330
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:2183 → 2218
    RHS_repeat; RHS Repeat
    pfam07974
    Location:1167 → 1194
    EGF_2; EGF-like domain
    pfam12955
    Location:1171 → 1235
    DUF3844; Domain of unknown function (DUF3844)
    pfam15636
    Location:3193 → 3268
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1750 → 2065
    NHL; NHL repeat unit of beta-propeller proteins
    cl22855
    Location:1069 → 1198
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  3. NM_001104191.3 → NP_001097661.2  tenascin major, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097661.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O61307
    Conserved Domains (12) summary
    COG3209
    Location:2347 → 3020
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1784 → 1830
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:2795 → 2836
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:2905 → 2980
    Rhs_assc_core; RHS repeat-associated core domain
    cd00185
    Location:1106 → 1151
    TNFRSF; CRD2 [structural motif]
    pfam01500
    Location:1162 → 1330
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:2183 → 2218
    RHS_repeat; RHS Repeat
    pfam07974
    Location:1167 → 1194
    EGF_2; EGF-like domain
    pfam12955
    Location:1171 → 1235
    DUF3844; Domain of unknown function (DUF3844)
    pfam15636
    Location:3193 → 3268
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1750 → 2065
    NHL; NHL repeat unit of beta-propeller proteins
    cl22855
    Location:1069 → 1198
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PGF7 M9PGF7
O61307.2 O61307
Q8T962 Q8T962

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