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map3k12 mitogen-activated protein kinase kinase kinase 12 [ Danio rerio (zebrafish) ]

Gene ID: 404626, updated on 27-Dec-2024

Summary

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Official Symbol
map3k12provided by ZNC
Official Full Name
mitogen-activated protein kinase kinase kinase 12provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2436
See related
Ensembl:ENSDARG00000103651 AllianceGenome:ZFIN:ZDB-GENE-040426-2436
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:77370
Summary
Predicted to enable ATP binding activity and MAP kinase kinase kinase activity. Predicted to act upstream of or within JNK cascade and protein autophosphorylation. Predicted to be located in cytoplasm. Is expressed in central nervous system; cranial ganglion; neural tube; neurons; and retina. Orthologous to human MAP3K12 (mitogen-activated protein kinase kinase kinase 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See map3k12 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (219112..239748)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (218676..236334)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene phospholipase B domain containing 2 Neighboring gene cyclin-dependent kinase 16 Neighboring gene achalasia, adrenocortical insufficiency, alacrimia Neighboring gene poly(rC) binding protein 2 Neighboring gene kinesin family member 5A, a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The MAP3Ks DLK and LZK Direct Diverse Responses to Axon Damage in Zebrafish Peripheral Neurons. Adula KP, et al. J Neurosci, 2022 Aug 10. PMID 35840323, Free PMC Article
  2. Zebrafish miR-462-731 regulates hematopoietic specification and pu.1-dependent primitive myelopoiesis. Huang CX, et al. Cell Death Differ, 2019 Aug. PMID 30459392, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC77370

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within JNK cascade IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 12
NP_996977.1
XP_005167446.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207094.1 → NP_996977.1  mitogen-activated protein kinase kinase kinase 12

    See identical proteins and their annotated locations for NP_996977.1

    Status: PROVISIONAL

    Source sequence(s)
    BC066441
    UniProtKB/TrEMBL
    A0A8M1PKL7, Q6NYW1
    Related
    ENSDARP00000130149.1, ENSDART00000161484.2
    Conserved Domains (2) summary
    smart00219
    Location:156 → 388
    TyrKc; Tyrosine kinase, catalytic domain
    cd14059
    Location:155 → 391
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    219112..239748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167389.5 → XP_005167446.1  mitogen-activated protein kinase kinase kinase 12 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BER7
    Conserved Domains (2) summary
    smart00219
    Location:156 → 388
    TyrKc; Tyrosine kinase, catalytic domain
    cd14059
    Location:155 → 391
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
Nucleotide Protein
Heading Accession and Version

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