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Rich RIC1 homolog [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40456, updated on 9-Dec-2024

Summary

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Official Symbol
Richprovided by FlyBase
Official Full Name
RIC1 homologprovided by FlyBase
Primary source
FLYBASE:FBgn0028500
Locus tag
Dmel_CG9063
See related
AllianceGenome:FB:FBgn0028500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
3L6; BcDNA:GH03694; BcDNAGH03694; CG9063; Dmel\CG9063; rich
Summary
Enables small GTPase binding activity. Involved in several processes, including neuron development; protein localization to synapse; and regulation of Rab protein signal transduction. Located in Golgi apparatus and cytoplasmic vesicle. Is expressed in several structures, including embryonic/larval optic lobe; eye disc; lamina anlage; medulla anlage; and synaptic neuropil domain. Orthologous to human RIC1 (RIC1 homolog, RAB6A GEF complex partner 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Rich in Genome Data Viewer
Location:
79D2-79D3; 3-47 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22257749..22262921, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22250849..22256021, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene olf413 Neighboring gene long non-coding RNA:CR45972 Neighboring gene long non-coding RNA:CR45035 Neighboring gene uncharacterized protein Neighboring gene stable intronic sequence RNA 3 Neighboring gene Dead-box-1 Neighboring gene Cysteine string protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila. Haag-Liautard C, et al. Nature, 2007 Jan 4. PMID 17203060
  2. Rab6 Is Required for Multiple Apical Transport Pathways but Not the Basolateral Transport Pathway in Drosophila Photoreceptors. Iwanami N, et al. PLoS Genet, 2016 Feb. PMID 26890939, Free PMC Article
  3. Rich regulates target specificity of photoreceptor cells and N-cadherin trafficking in the Drosophila visual system via Rab6. Tong C, et al. Neuron, 2011 Aug 11. PMID 21835342, Free PMC Article
  4. The two TRAPP complexes of metazoans have distinct roles and act on different Rab GTPases. Riedel F, et al. J Cell Biol, 2018 Feb 5. PMID 29273580, Free PMC Article
  5. The Crossroads of Synaptic Growth Signaling, Membrane Traffic and Neurological Disease: Insights from Drosophila. Deshpande M, et al. Traffic, 2016 Feb. PMID 26538429

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in R7 cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Rab protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex IEA
Inferred from Electronic Annotation
more info
  
part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
RIC1 homolog
Names
CG9063-PA
CG9063-PB
Rich-PA
Rich-PB
ric1 homolog
ric1 homologue

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    22257749..22262921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275276.1 → NP_001262205.1  RIC1 homolog, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9PG00, Q9V3C5
    Conserved Domains (2) summary
    pfam07064
    Location:713 → 974
    RIC1; RIC1
    sd00039
    Location:265 → 312
    7WD40; WD40 repeat [structural motif]

  2. NM_141128.3 → NP_649385.1  RIC1 homolog, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649385.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9PG00, Q9V3C5
    Related
    FBpp0078164
    Conserved Domains (2) summary
    pfam07064
    Location:713 → 974
    RIC1; RIC1
    sd00039
    Location:265 → 312
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3C5.1 Q9V3C5

Gene LinkOut

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