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P5CDh1 delta-1-Pyrroline-5-carboxylate dehydrogenase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40434, updated on 9-Dec-2024

Summary

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Official Symbol
P5CDh1provided by FlyBase
Official Full Name
delta-1-Pyrroline-5-carboxylate dehydrogenase 1provided by FlyBase
Primary source
FLYBASE:FBgn0037138
Locus tag
Dmel_CG7145
See related
AllianceGenome:FB:FBgn0037138
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7145; Dmel\CG7145; DmP5CDh1; P5CDh
Summary
Predicted to enable 1-pyrroline-5-carboxylate dehydrogenase activity. Involved in proline metabolic process. Located in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Used to study hyperprolinemia type 2. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See P5CDh1 in Genome Data Viewer
Location:
78F4-78F4; 3-47 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21836665..21841356, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21829765..21834456, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Nopp140 Neighboring gene transfer RNA:Cysteine-GCA 4-1 Neighboring gene uncharacterized protein Neighboring gene mushroom-body expressed

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequences, phylogeny and evolution of mitochondrial delta-1-pyrroline-5-carboxylate dehydrogenases (ALDH4A1). Evidence for a second locus (ALDH4A2) in Drosophila. Holmes RS. Chem Biol Interact, 2023 Sep 25. PMID 37597643
  2. Drosophila delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDh) is required for proline breakdown and mitochondrial integrity-Establishing a fly model for human type II hyperprolinemia. He F, et al. Mitochondrion, 2011 May. PMID 21168532
  3. Deletion of Drosophila Nopp140 induces subcellular ribosomopathies. He F, et al. Chromosoma, 2015 Jun. PMID 25384888
  4. Filtering of Data-Driven Gene Regulatory Networks Using Drosophila melanogaster as a Case Study. Cuesta-Astroz Y, et al. Front Genet, 2021. PMID 34394179, Free PMC Article
  5. The quantitative genetic basis of male mating behavior in Drosophila melanogaster. Moehring AJ, et al. Genetics, 2004 Jul. PMID 15280239, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Homozygous (CG7145(f04633)/CG7145(f04633)) individuals displayed proline levels twice that of normal, swollen mitochondria, and ultimately larval and pupal lethality.
    Title: Drosophila delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDh) is required for proline breakdown and mitochondrial integrity-Establishing a fly model for human type II hyperprolinemia.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 1-pyrroline-5-carboxylate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-pyrroline-5-carboxylate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proline catabolic process to glutamate IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proline catabolic process to glutamate IEA
Inferred from Electronic Annotation
more info
  
involved_in proline metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
delta-1-Pyrroline-5-carboxylate dehydrogenase 1
Names
CG7145-PA
CG7145-PB
CG7145-PD
CG7145-PE
CG7145-PF
P5CDh1-PA
P5CDh1-PB
P5CDh1-PD
P5CDh1-PE
P5CDh1-PF
delta-1-pyrroline-5-carboxylate dehydrogenase
NP_001189159.1
NP_001262196.1
NP_649368.2
NP_730695.1
NP_730698.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21836665..21841356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168945.5 → NP_730698.1  delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730698.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3P0, Q9VNX4
    Related
    FBpp0078101
    Conserved Domains (1) summary
    cd07123
    Location:41 → 563
    ALDH_F4-17_P5CDH; Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17

  2. NM_168942.5 → NP_730695.1  delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730695.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3P0, Q9VNX4
    Related
    FBpp0078099
    Conserved Domains (1) summary
    cd07123
    Location:41 → 563
    ALDH_F4-17_P5CDH; Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17

  3. NM_001275267.1 → NP_001262196.1  delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262196.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3P0, Q9VNX4
    Conserved Domains (1) summary
    cd07123
    Location:41 → 563
    ALDH_F4-17_P5CDH; Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17

  4. NM_001202230.2 → NP_001189159.1  delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189159.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3P0, Q9VNX4
    Conserved Domains (1) summary
    cd07123
    Location:41 → 563
    ALDH_F4-17_P5CDH; Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17

  5. NM_141111.6 → NP_649368.2  delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649368.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3P0, Q9VNX4
    Related
    FBpp0078100
    Conserved Domains (1) summary
    cd07123
    Location:41 → 563
    ALDH_F4-17_P5CDH; Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T3P0 Q8T3P0
Q9VNX4 Q9VNX4

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