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Nopp140 Nopp140 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40433, updated on 4-Jan-2025

Summary

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Official Symbol
Nopp140provided by FlyBase
Official Full Name
Nopp140provided by FlyBase
Primary source
FLYBASE:FBgn0037137
Locus tag
Dmel_CG7421
See related
AllianceGenome:FB:FBgn0037137
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7421; Dmel\CG7421; DmNopp140; NCL; Nopp- 140; nopp140
Summary
Involved in rRNA 2'-O-methylation. Located in nucleolus. Is expressed in several structures, including adult head; antennal primordium; embryonic/larval midgut primordium; head epidermis primordium; and larval muscle cell. Orthologous to human NOLC1 (nucleolar and coiled-body phosphoprotein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Nopp140 in Genome Data Viewer
Location:
78F4-78F4; 3-47 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21832774..21836685)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21825874..21829785)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene delta-1-Pyrroline-5-carboxylate dehydrogenase 1 Neighboring gene transfer RNA:Cysteine-GCA 4-1 Neighboring gene uncharacterized protein Neighboring gene mushroom-body expressed

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two splice variants of Nopp140 in Drosophila melanogaster. Waggener JM, et al. Mol Biol Cell, 2002 Jan. PMID 11809845, Free PMC Article
  2. R1 retrotransposons in the nucleolar organizers of Drosophila melanogaster are transcribed by RNA polymerase I upon heat shock. Raje HS, et al. Transcription, 2018. PMID 30063880, Free PMC Article
  3. Tracking nucleolar dynamics with GFP-Nopp140 during Drosophila oogenesis and embryogenesis. McCain J, et al. Cell Tissue Res, 2006 Jan. PMID 16158326
  4. The Nopp140 gene in Drosophila melanogaster displays length polymorphisms in its large repetitive second exon. Baral SS, et al. Mol Genet Genomics, 2019 Aug. PMID 31006039
  5. RNAi knockdown of Nopp140 induces Minute-like phenotypes in Drosophila. Cui Z, et al. Mol Biol Cell, 2007 Jun. PMID 17392509, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nopp140 is not required for overall nucleolar integrity, but is required for 2'-O-methylation. Loss of Nopp140 impairs 2'-O-methylation of 18S and 28S rRNA.
    Title: Deletion of Drosophila Nopp140 induces subcellular ribosomopathies.
  2. occurrence of apoptosis, autophagy and phenoloxidase A3 release to the hemolymph upon nucleolar stress correlated well with the demonstrated activation of Jun N-terminal kinase (JNK) in Nopp140-depleted larvae
    Title: Nucleolar stress in Drosophila melanogaster: RNAi-mediated depletion of Nopp140.
  3. Data show that RNAi knockdown of Nopp140 induces Minute-like phenotypes in Drosophila that are reminiscent of human craniofacial malformations associated with Treacher Collins syndrome.
    Title: RNAi knockdown of Nopp140 induces Minute-like phenotypes in Drosophila.
  4. Pole cells contained GFP-Nopp140 during the syncytial embryonic stages, but their nucleologenesis started at gastrulation.
    Title: Tracking nucleolar dynamics with GFP-Nopp140 during Drosophila oogenesis and embryogenesis.
  5. Two splice variants of Nopp140
    Title: Two splice variants of Nopp140 in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in rRNA 2'-O-methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Nopp140
Names
CG7421-PA
CG7421-PB
CG7421-PE
CG7421-PF
Nopp140-PA
Nopp140-PB
Nopp140-PE
Nopp140-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21832774..21836685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275266.1 → NP_001262195.1  Nopp140, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262195.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFZ1, Q7Z2C9

  2. NM_168940.3 → NP_730693.1  Nopp140, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730693.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTV5, Q7Z2C9
    Related
    FBpp0088542
    Conserved Domains (1) summary
    pfam05022
    Location:613 → 678
    SRP40_C; SRP40, C-terminal domain

  3. NM_001202229.2 → NP_001189158.2  Nopp140, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189158.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MSM4, Q7Z2C9
    Conserved Domains (1) summary
    pfam05022
    Location:612 → 677
    SRP40_C; SRP40, C-terminal domain

  4. NM_168941.4 → NP_730694.2  Nopp140, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730694.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7Z2C9, Q9VNX5, Q9VNX6
    Related
    FBpp0089003
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9MSM4 M9MSM4
M9PFZ1 M9PFZ1
Q7KTV5 Q7KTV5
Q7Z2C9 Q7Z2C9
Q95RR9 Q95RR9
Q9VNX6 Q9VNX6

Gene LinkOut

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