MED1 Mediator complex subunit 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: MED1provided by FlyBase
Official Full Name: Mediator complex subunit 1provided by FlyBase
Primary source: FLYBASE:FBgn0037109
Locus tag: Dmel_CG7162
See related: AllianceGenome:FB:FBgn0037109
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7162; Dmel\CG7162; dTRAP220; FBgn0037109; Med1; Med1/SOP3/TRAP220; Trap220
Summary: Enables transcription coregulator activity. Involved in positive regulation of transcription by RNA polymerase II. Part of mediator complex. Is expressed in organism. Orthologous to human MED1 (mediator complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (21628325..21634446, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (21621425..21627546, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Mediator complex subunit Med19 binds directly GATA transcription factors and is required with Med1 for GATA-driven gene regulation in vivo.
Title: Mediator complex subunit Med19 binds directly GATA transcription factors and is required with Med1 for GATA-driven gene regulation in vivo.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info
enables transcription coregulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coregulator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IC Inferred by Curator more info	PubMed
part_of mediator complex	IEA Inferred from Electronic Annotation more info
part_of mediator complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of mediator complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	IC Inferred by Curator more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain