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Aef1 Adult enhancer factor 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40370, updated on 9-Dec-2024

Summary

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Official Symbol
Aef1provided by FlyBase
Official Full Name
Adult enhancer factor 1provided by FlyBase
Primary source
FLYBASE:FBgn0005694
Locus tag
Dmel_CG5683
See related
AllianceGenome:FB:FBgn0005694
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AEF-1; aef1; AEF1; CG5683; Dmel\CG5683
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic/larval midgut; olfactory receptor neurons; and organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Aef1 in Genome Data Viewer
Location:
78D2-78D2; 3-47 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21433422..21438639)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21426522..21431739)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene regeneration Neighboring gene long non-coding RNA:CR45954 Neighboring gene barricade Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Alkaline phosphatase 1 Neighboring gene Syntaxin 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A UAS site substitution approach to the in vivo dissection of promoters: interplay between the GATAb activator and the AEF-1 repressor at a Drosophila ecdysone response unit. Brodu V, et al. Development, 2001 Jul. PMID 11493575
  2. The adult enhancer factor-1, a Drosophila melanogaster transcriptional repressor, modulates the promoter activity of the rat class-I alcohol dehydrogenase-encoding gene. Potter JJ, et al. Gene, 1994 Nov 18. PMID 7959011
  3. Regulation of Drosophila Adh promoter switching by an initiator-targeted repression mechanism. Ren B, et al. EMBO J, 1998 Feb 16. PMID 9463385, Free PMC Article
  4. Drosophila transcriptional repressor protein that binds specifically to negative control elements in fat body enhancers. Falb D, et al. Mol Cell Biol, 1992 Sep. PMID 1508206, Free PMC Article
  5. A conserved regulatory unit implicated in tissue-specific gene expression in Drosophila and man. Falb D, et al. Genes Dev, 1992 Mar. PMID 1547943

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adult enhancer factor 1
Names
Adh enhancer factor 1
Aef1-PA
Aef1-PB
Aef1-PC
Aef1-PD
CG5683-PA
CG5683-PB
CG5683-PC
CG5683-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21433422..21438639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275228.1 → NP_001262157.1  adult enhancer factor 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262157.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PG42
    Conserved Domains (2) summary
    sd00017
    Location:186 → 206
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:199 → 223
    zf-H2C2_2; Zinc-finger double domain

  2. NM_168904.3 → NP_730631.1  adult enhancer factor 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730631.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P39413, Q0E8C4, Q9VP37
    UniProtKB/TrEMBL
    A4V287
    Related
    FBpp0078005
    Conserved Domains (2) summary
    sd00017
    Location:186 → 206
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:199 → 223
    zf-H2C2_2; Zinc-finger double domain

  3. NM_168903.3 → NP_730630.1  adult enhancer factor 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730630.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P39413, Q0E8C4, Q9VP37
    UniProtKB/TrEMBL
    A4V287
    Related
    FBpp0078004
    Conserved Domains (2) summary
    sd00017
    Location:186 → 206
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:199 → 223
    zf-H2C2_2; Zinc-finger double domain

  4. NM_079476.3 → NP_524200.1  adult enhancer factor 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524200.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P39413, Q0E8C4, Q9VP37
    UniProtKB/TrEMBL
    A4V287
    Related
    FBpp0078006
    Conserved Domains (2) summary
    sd00017
    Location:186 → 206
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:199 → 223
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V287 A4V287
M9PG42 M9PG42
P39413.1 P39413

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