U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rab26 Rab26 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40359, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Rab26provided by FlyBase
Official Full Name
Rab26provided by FlyBase
Primary source
FLYBASE:FBgn0086913
Locus tag
Dmel_CG34410
See related
AllianceGenome:FB:FBgn0086913
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AAF51708; CG32439; CG34410; CG7605; Dmel\CG34410; DmRab26; Q8IPT6; Q9VP48; rab26
Old locus tag
CG32439; CG7605; Dmel_CG32439; Dmel_CG7605
Summary
Predicted to enable GTP binding activity and GTPase activity. Involved in symbiont entry into host cell. Located in recycling endosome and synapse. Is expressed in several structures, including Bolwig organ; adult head; brain; mushroom body; and synaptic neuropil domain. Orthologous to several human genes including RAB37 (RAB37, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rab26 in Genome Data Viewer
Location:
78C7-78C7; 3-47 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21318774..21335027)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21311874..21328127)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Polycomb Neighboring gene long non-coding RNA:CR45674 Neighboring gene antisense RNA:CR46068 Neighboring gene TBC1 domain family member 8/9 Neighboring gene Tsr1 ribosome assembly factor Neighboring gene uncharacterized protein Neighboring gene earthbound 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The GTPase Rab26 links synaptic vesicles to the autophagy pathway. Binotti B, et al. Elife, 2015 Feb 2. PMID 25643395, Free PMC Article
  2. Rab26 controls secretory granule maturation and breakdown in Drosophila. Boda A, et al. Cell Mol Life Sci, 2023 Jan 4. PMID 36600084, Free PMC Article
  3. Local endocytosis triggers dendritic thinning and pruning in Drosophila sensory neurons. Kanamori T, et al. Nat Commun, 2015 Mar 12. PMID 25761586
  4. Commissureless regulation of axon outgrowth across the midline is independent of Rab function. van den Brink DM, et al. PLoS One, 2013. PMID 23696892, Free PMC Article
  5. Huntingtin differentially regulates the axonal transport of a sub-set of Rab-containing vesicles in vivo. White JA 2nd, et al. Hum Mol Genet, 2015 Dec 20. PMID 26450517, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rab26 controls secretory granule maturation and breakdown in Drosophila.
    Title: Rab26 controls secretory granule maturation and breakdown in Drosophila.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Rab protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in symbiont entry into host cell HMP PubMed 
involved_in vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in recycling endosome HDA PubMed 
located_in synapse HDA PubMed 
located_in vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Rab26
Names
CG34410-PB
CG34410-PC
CG34410-PD
CG34410-PE
CG34410-PF
CG34410-PG
Rab26-PB
Rab26-PC
Rab26-PD
Rab26-PE
Rab26-PF
Rab26-PG

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21318774..21335027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300213.1 → NP_001287142.1  Rab26, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287142.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95R32, Q9VP48
    UniProtKB/TrEMBL
    B5RJ70
    Conserved Domains (2) summary
    smart00175
    Location:192 → 356
    RAB; Rab subfamily of small GTPases
    cd04112
    Location:191 → 385
    Rab26; Rab GTPase family 26 (Rab26)

  2. NM_001275222.1 → NP_001262151.1  Rab26, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262151.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V496, Q4V4D6, Q8IPT6
    Conserved Domains (2) summary
    smart00175
    Location:214 → 378
    RAB; Rab subfamily of small GTPases
    cd04112
    Location:214 → 407
    Rab26; Rab GTPase family 26 (Rab26)

  3. NM_141046.4 → NP_649303.2  Rab26, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649303.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95R32, Q9VP48
    UniProtKB/TrEMBL
    B5RJ70
    Related
    FBpp0111589
    Conserved Domains (2) summary
    smart00175
    Location:192 → 356
    RAB; Rab subfamily of small GTPases
    cd04112
    Location:191 → 385
    Rab26; Rab GTPase family 26 (Rab26)

  4. NM_001104188.3 → NP_001097658.1  Rab26, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097658.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V496, Q4V4D6, Q8IPT6
    Conserved Domains (2) summary
    smart00175
    Location:214 → 378
    RAB; Rab subfamily of small GTPases
    cd04112
    Location:214 → 407
    Rab26; Rab GTPase family 26 (Rab26)

  5. NM_001170017.1 → NP_001163488.1  Rab26, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163488.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V496, Q4V4D6, Q8IPT6
    Conserved Domains (2) summary
    smart00175
    Location:214 → 378
    RAB; Rab subfamily of small GTPases
    cd04112
    Location:214 → 407
    Rab26; Rab GTPase family 26 (Rab26)

  6. NM_001275223.1 → NP_001262152.1  Rab26, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262152.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PG39, Q4V4D6
    Conserved Domains (1) summary
    cl21455
    Location:211 → 370
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B5RJ70 B5RJ70
M9PG39 M9PG39
Q8IPT6 Q8IPT6
Q9VP48.2 Q9VP48

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous