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CG10565 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40332, updated on 17-Dec-2024

Summary

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Official Symbol
CG10565provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037051
Locus tag
Dmel_CG10565
See related
AllianceGenome:FB:FBgn0037051
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG10565; zuo1
Summary
Predicted to enable Hsp70 protein binding activity and ribosome binding activity. Predicted to be involved in 'de novo' cotranslational protein folding. Predicted to be active in cytosol. Is expressed in several structures, including adult head; anal pad primordium; embryonic/larval midgut primordium; gut section; and larval muscle cell. Orthologous to human DNAJC2 (DnaJ heat shock protein family (Hsp40) member C2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG10565 in Genome Data Viewer
Location:
78B2-78B3; 3-47 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21133250..21136353, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21126350..21129453, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene knockout Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Islet cell autoantigen 69 kDa Neighboring gene Adenylyl cyclase 78C Neighboring gene Asparagine synthetase Neighboring gene chromosome bows

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of protein quality control regulators using a Drosophila model of TPI deficiency. Hrizo SL, et al. Neurobiol Dis, 2021 May. PMID 33600953, Free PMC Article
  2. Regulatory Mechanisms of Metamorphic Neuronal Remodeling Revealed Through a Genome-Wide Modifier Screen in Drosophila melanogaster. Chen D, et al. Genetics, 2017 Jul. PMID 28476867, Free PMC Article
  3. Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP-PKA signaling. Machado Almeida P, et al. Nat Commun, 2021 Oct 1. PMID 34599173, Free PMC Article
  4. The Splicing Factor SF2 Is Critical for Hyperproliferation and Survival in a TORC1-Dependent Model of Early Tumorigenesis in Drosophila. Parniewska MM, et al. Int J Mol Sci, 2020 Jun 24. PMID 32599686, Free PMC Article
  5. FACS purification and transcriptome analysis of drosophila neural stem cells reveals a role for Klumpfuss in self-renewal. Berger C, et al. Cell Rep, 2012 Aug 30. PMID 22884370, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' cotranslational protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' cotranslational protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational fidelity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG10565-PA
CG10565-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21133250..21136353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259927.1 → NP_001246856.1  uncharacterized protein Dmel_CG10565, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246856.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VP77
    Conserved Domains (6) summary
    smart00717
    Location:584 → 633
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    COG2214
    Location:76 → 282
    CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]
    cd00167
    Location:585 → 632
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam00226
    Location:76 → 145
    DnaJ; DnaJ domain
    pfam16717
    Location:332 → 401
    RAC_head; Ribosome-associated complex head domain
    cl23720
    Location:268 → 344
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  2. NM_141027.4 → NP_649284.1  uncharacterized protein Dmel_CG10565, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649284.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VP77
    Related
    FBpp0077979
    Conserved Domains (6) summary
    smart00717
    Location:584 → 633
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    COG2214
    Location:76 → 282
    CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]
    cd00167
    Location:585 → 632
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam00226
    Location:76 → 145
    DnaJ; DnaJ domain
    pfam16717
    Location:332 → 401
    RAC_head; Ribosome-associated complex head domain
    cl23720
    Location:268 → 344
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VP77 Q9VP77

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