igfbp3 insulin-like growth factor binding protein 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: igfbp3provided by ZNC
Official Full Name: insulin-like growth factor binding protein 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-040412-1
See related: Ensembl:ENSDARG00000099144 AllianceGenome:ZFIN:ZDB-GENE-040412-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: IGFBP-3; zgc:91788
Summary: Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Acts upstream of or within several processes, including insulin-like growth factor receptor signaling pathway; negative regulation of BMP signaling pathway; and otic vesicle formation. Located in nucleus. Is expressed in several structures, including female organism; nervous system; neural crest telencephalon; otic vesicle; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Orthologous to human IGFBP3 (insulin like growth factor binding protein 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (6773777..6804237)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (6783830..6814290)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

insulin-like growth factor binding protein 3 exerts its ligand-independent action by antagonizing bone morphogenetic protein 2 in zebrafish embryos
Title: IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos.
IGFBP-3 plays an important role in regulating pharyngeal cartilage and inner ear development and growth in zebrafish.
Title: Insulin-like growth factor-binding protein-3 plays an important role in regulating pharyngeal skeleton and inner ear formation and differentiation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables fibronectin binding	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor I binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor I binding	IDA Inferred from Direct Assay more info	PubMed
enables insulin-like growth factor II binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor II binding	IDA Inferred from Direct Assay more info	PubMed
enables insulin-like growth factor binding	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within otic vesicle formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pharyngeal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
part_of insulin-like growth factor binding protein complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: insulin-like growth factor-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205751.2 → NP_991314.2 insulin-like growth factor-binding protein 3 precursor

See identical proteins and their annotated locations for NP_991314.2

Status: PROVISIONAL

Source sequence(s)

BC081574

UniProtKB/TrEMBL

A0A8M1PF12, Q66I28

Related

ENSDARP00000135216.1, ENSDART00000169966.2

Conserved Domains (2) summary

smart00121
Location:27 → 104

IB; Insulin growth factor-binding protein homologues

pfam00086
Location:216 → 277

Thyroglobulin_1; Thyroglobulin type-1 repeat