smc1al structural maintenance of chromosomes 1A, like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: smc1alprovided by ZNC
Official Full Name: structural maintenance of chromosomes 1A, likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-57
See related: Ensembl:ENSDARG00000058203 AllianceGenome:ZFIN:ZDB-GENE-040426-57
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: smc1a; smc1l1; zgc:76902; im:7158706
Summary: Predicted to enable DNA binding activity. Acts upstream of or within embryonic viscerocranium morphogenesis. Predicted to be located in chromosome. Predicted to be part of meiotic cohesin complex. Predicted to be active in nucleus. Is expressed in several structures, including cranium; digestive system; nervous system; optic cup; and otic vesicle. Used to study Cornelia de Lange syndrome. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 2; congestive heart failure; and developmental and epileptic encephalopathy 85. Orthologous to human SMC1A (structural maintenance of chromosomes 1A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (12840100..12897576)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (13084023..13141499)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fk74g06.x1 (e-PCR)
- UniSTS:201496

fb40g11.x1 (e-PCR)
- UniSTS:187200

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromosome organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sister chromatid cohesion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of cohesin complex	IEA Inferred from Electronic Annotation more info
part_of meiotic cohesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: structural maintenance of chromosomes 1A, like

Names: SMC1 structural maintenance of chromosomes 1-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212810.2 → NP_997975.2 structural maintenance of chromosomes 1A, like

See identical proteins and their annotated locations for NP_997975.2

Status: PROVISIONAL

Source sequence(s)

AY648730

UniProtKB/TrEMBL

A0A8N7V0B7, Q6DRM9

Related

ENSDARP00000075459.2, ENSDART00000081016.4

Conserved Domains (3) summary

cd03275
Location:4 → 148

ABC_SMC1_euk; ATP-binding cassette domain of eukaryotic SMC1 proteins

smart00968
Location:513 → 628

SMC_hinge; SMC proteins Flexible Hinge Domain

pfam02463
Location:3 → 1209

SMC_N; RecF/RecN/SMC N terminal domain